M7GpppN-mRNA hydrolase

M7GpppN-mRNA hydrolase
Identifiers
EC number 3.6.1.62
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

M7GpppN-mRNA hydrolase (EC 3.6.1.62, DCP2, NUDT16, D10 protein, D9 protein, D10 decapping enzyme, decapping enzyme) is an enzyme with systematic name m7GpppN-mRNA m7GDP phosphohydrolase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

m7G5'ppp5'-mRNA + H2O m7GDP + 5'-phospho-mRNA

Decapping of mRNA is essential in eukaryotic mRNA turnover.

References

  1. ↑ Xu, J.; Yang, J.Y.; Niu, Q.W.; Chua, N.H. (2006). "Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development". Plant Cell. 18: 3386–3398. doi:10.1105/tpc.106.047605. PMC 1785416. PMID 17158604.
  2. ↑ Lu, G.; Zhang, J.; Li, Y.; Li, Z.; Zhang, N.; Xu, X.; Wang, T.; Guan, Z.; Gao, G.F.; Yan, J. (2011). "hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA". Protein Cell. 2: 64–73. doi:10.1007/s13238-011-1009-2. PMC 4875290. PMID 21337011.
  3. ↑ van Dijk, E.; Cougot, N.; Meyer, S.; Babajko, S.; Wahle, E.; Seraphin, B. (2002). "Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures". EMBO J. 21: 6915–6924. doi:10.1093/emboj/cdf678. PMC 139098. PMID 12486012.
  4. ↑ Parrish, S.; Resch, W.; Moss, B. (2007). "Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression". Proc. Natl. Acad. Sci. USA. 104: 2139–2144. doi:10.1073/pnas.0611685104. PMC 1793903. PMID 17283339.
  5. ↑ Souliere, M.F.; Perreault, J.P.; Bisaillon, M. (2009). "Characterization of the vaccinia virus D10 decapping enzyme provides evidence for a two-metal-ion mechanism". Biochem. J. 420: 27–35. doi:10.1042/BJ20082296. PMID 19210265.
  6. ↑ Parrish, S.; Moss, B. (2007). "Characterization of a second vaccinia virus mRNA-decapping enzyme conserved in poxviruses". J. Virol. 81: 12973–12978. doi:10.1128/JVI.01668-07. PMC 2169080. PMID 17881455.
  7. ↑ Song, M.G.; Li, Y.; Kiledjian, M. (2010). "Multiple mRNA decapping enzymes in mammalian cells". Mol. Cell. 40: 423–432. doi:10.1016/j.molcel.2010.10.010. PMC 2982215. PMID 21070968.
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