Lecithinase C

Phospholipase C
Identifiers
EC number 3.1.4.3
CAS number 9001-86-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Phospholipase C (EC 3.1.4.3, lipophosphodiesterase I, Clostridium welchii alpha-toxin, Clostridium oedematiens beta- and gamma-toxins, lipophosphodiesterase C, phosphatidase C, heat-labile hemolysin, alpha-toxin) is an enzyme with systematic name phosphatidylcholine cholinephosphohydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction

a phosphatidylcholine + H2O 1,2-diacyl-sn-glycerol + phosphocholine

The bacterial enzyme is a zinc protein. It also acts on sphingomyelin and phosphatidylinositol.

References

  1. ↑ Druzhinina KV, Kritsman MG (1952). "[Lecithinase C in animal tissue]". Biokhimiia. 17 (1): 77–81. PMID 13066482.
  2. ↑ Little C, Otnåss AB (June 1975). "The metal ion dependence of phospholipase C from Bacillus cereus". Biochimica et Biophysica Acta. 391 (2): 326–33. doi:10.1016/0005-2744(75)90256-9. PMID 807246.
  3. ↑ Sheikhnejad RG, Srivastava PN (June 1986). "Isolation and properties of a phosphatidylcholine-specific phospholipase C from bull seminal plasma". The Journal of Biological Chemistry. 261 (16): 7544–9. PMID 3086312.
  4. ↑ Takahashi T, Sugahara T, Ohsaka A (May 1974). "Purification of Clostridium perfringens phospholipase C (alpha-toxin) by affinity chromatography on agarose-linked egg-yolk lipoprotein". Biochimica et Biophysica Acta. 351 (1): 155–71. doi:10.1016/0005-2795(74)90074-9. PMID 4365891.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.