Kaempferide

Kaempferide
Names
IUPAC name
3,5,7-trihydroxy-2-(4-methoxyphenyl)chromen-4-one
Other names
Kaempferid
4'-Methylkaempferol
Kaempferol 4'-methyl ether
4'-O-Methylkaempferol
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.007.036
KEGG
Properties
C16H12O6
Molar mass 300.26 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Kaempferide is an O-methylated flavonol, a type of chemical compound. It can be found in Kaempferia galanga (aromatic ginger). It has been noted to inhibit pancreatic cancer growth by blockading an EGFR-related pathway.[1]

Metabolism

The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L-methionine and kaempferol to produce S-adenosyl-L-homocysteine and kaempferide.

Glycosides

Icariin is the tert-amyl alcohol derivative of kaempferide 3,7-O-diglycoside.

  1. Lee, Jungwhoi; Kim, Jae Hoon (2016). "Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro". PLOS ONE. 11 (5): e0155264. doi:10.1371/journal.pone.0155264. PMC 4866780. PMID 27175782.
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