Inorganic diphosphatase

inorganic diphosphatase
Pyrophosphatase (inorganic) hexamer, E.Coli
Identifiers
EC number 3.6.1.1
CAS number 9024-82-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, an inorganic diphosphatase (EC 3.6.1.1) is an enzyme that catalyzes the chemical reaction

diphosphate + H2O 2 phosphate

Thus, the two substrates of this enzyme are diphosphate and H2O, whereas its product is phosphate.[1]

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is diphosphate phosphohydrolase. This enzyme participates in oxidative phosphorylation. It employs one cofactor, metal.

References

  1. ↑ Rafter GW (1960). "Pyrophosphate metabolism in liver mitochondria". J. Biol. Chem. 235: 2475&ndash, 2477.

Further reading

  • Bailey K; Webb EC (1944). "Purification and properties of yeast pyrophosphatase". Biochem. J. 38 (5): 394&ndash, 398. PMC 1258115. PMID 16747821.
  • KUNITZ M (1952). "CRYSTALLINE INORGANIC PYROPHOSPHATASE ISOLATED FROM BAKER'S YEAST". J. Gen. Physiol. 35 (3): 423&ndash, 50. doi:10.1085/jgp.35.3.423. PMC 2147340. PMID 14898026.
  • Sarafian V, Kim Y, Poole RJ, Rea PA (March 1992). "Molecular cloning and sequence of cDNA encoding the pyrophosphate-energized vacuolar membrane proton pump of Arabidopsis thaliana". Proc. Natl. Acad. Sci. U.S.A. 89 (5): 1775–9. doi:10.1073/pnas.89.5.1775. PMC 48535. PMID 1311852.
  • Drozdowicz YM, Lu YP, Patel V, Fitz-Gibbon S, Miller JH, Rea PA (November 1999). "A thermostable vacuolar-type membrane pyrophosphatase from the archaeon Pyrobaculum aerophilum: implications for the origins of pyrophosphate-energized pumps". FEBS Lett. 460 (3): 505–12. doi:10.1016/S0014-5793(99)01404-0. PMID 10556526.
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