HEPPS (buffer)

HEPPS
Names
IUPAC name
3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
Other names
HEPPS, EPPS
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.036.528
Properties
C9H20N2O4S
Molar mass 252.33 g·mol−1
Melting point (decomposes)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

HEPPS (EPPS) is a buffering agent used in biology and biochemistry. The pKa of HEPPS is 8.00. It is ones of Good's buffers.[1]

Research on mice with Alzheimers disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice.[2][3][4]

References

  1. ↑ Good, N. E; Winget, G. D; Winter, W; Connolly, T. N; Izawa, S; Singh, R. M (1966). "Hydrogen ion buffers for biological research". Biochemistry. 5 (2): 467–77. PMID 5942950.
  2. ↑ "Small Molecule Breaks Up Amyloid Aggregates In Mice". Chemical & Engineering News. Retrieved 14 December 2015.
  3. ↑ Kim, Hye Yun; Kim, Hyunjin Vincent; Jo, Seonmi; Lee, C. Justin; Choi, Seon Young; Kim, Dong Jin; Kim, YoungSoo (8 December 2015). "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques". Nature Communications. 6: 8997. doi:10.1038/ncomms9997. PMC 4686862. PMID 26646366.
  4. ↑ "Chemical clears Alzheimer's protein and restores memory in mice". MedicalXpress. Retrieved December 10, 2015.

See also


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