2,3-Dichlorophenylpiperazine
Names | |
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IUPAC name
1-(2,3-dichlorophenyl)piperazine | |
Identifiers | |
3D model (JSmol) |
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ChemSpider | |
ECHA InfoCard | 100.126.497 |
PubChem CID |
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Properties | |
C10H12Cl2N2 | |
Molar mass | 231.12 g/mol |
Appearance | brown oil |
Density | 1.272g/cm3 °C |
Melting point | 242 to 244 °C (468 to 471 °F; 515 to 517 K) |
Boiling point | 365.1 °C (689.2 °F; 638.2 K) at 760mmHg |
Hazards | |
Flash point | 174.6 °C (346.3 °F; 447.8 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
2,3-Dichlorophenylpiperazine (2,3-DCPP or DCPP) is a chemical compound. It is both a precursor in the synthesis of aripiprazole and one of its metabolites.[1][2] It is unclear whether 2,3-DCPP is pharmacologically active similar to its close analogue 3-chlorophenylpiperazine (mCPP).
Legality
2,3-DCPP has been made illegal in Japan and Hungary after having been identified in seized designer drug samples.[3][4]
Derivatives
As with the related compound mCPP, 2,3-DCPP is an essential precursor to several pharmaceutical drugs which are widely used in medicine, and is also formed as a metabolite of these drugs in patients, although generally only in insignificant amounts.
See also
References
- ↑ Leś A, Badowska-Rosłonek K, Łaszcz M, Kamieńska-Duda A, Baran P, Kaczmarek Ł (2010). "Optimization of aripiprazole synthesis". Acta Poloniae Pharmaceutica. 67 (2): 151–7. PMID 20369792.
- ↑ Caccia S (August 2007). "N-dealkylation of arylpiperazine derivatives: disposition and metabolism of the 1-aryl-piperazines formed". Current Drug Metabolism. 8 (6): 612–22. doi:10.2174/138920007781368908. PMID 17691920.
- ↑ "指定薬物名称・構造式一覧(平成27年9月16日現在)" (PDF) (in Japanese). 厚生労働省. 16 September 2015. Retrieved 6 January 2015.
- ↑ A Magyarországon megjelent, a Kábítószer és Kábítószer-függőség Európai Megfigyelő Központjának Korai Jelzőrendszerébe (EMCDDA EWS) 2005 óta bejelentett ellenőrzött anyagok büntetőjogi vonatkozású besorolása
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