Epsilon cell

Epsilon cell
Details
Location Islets of Langerhans
Function Ghrelin production
Identifiers
TH H3.04.02.0.00038
Anatomical terms of microanatomy

Epsilon cells (ε-cells) are endocrine cells found in the Islets of Langerhans and produce the hormone ghrelin. They were discovered in mice.

Epsilon Cells During Development

In human fetal pancreases, single epsilon cells scattered in primitive exocrine tissue were observed to start aggregating into clusters after gestational week 13. From gestational week 21, epsilon cells were observed around developing islets, forming an almost continuous layer at the rim of the islets. In adult pancreas samples, they remained localized on the mantle of the islets in different amounts. Production of ghrelin with insulin, glucagon, or somatostatin was not detected during development. Co-production with pancreatic polypeptide was evident sporadically.[1]

See also

References

  1. ↑ Andralojc, K. M; Mercalli, A; Nowak, K. W; Albarello, L; Calcagno, R; Luzi, L; Bonifacio, E; Doglioni, C; Piemonti, L (2008). "Ghrelin-producing epsilon cells in the developing and adult human pancreas". Diabetologia. 52 (3): 486–93. doi:10.1007/s00125-008-1238-y. PMID 19096824.
  • https://web.archive.org/web/20101128140558/http://www.diamap.eu/report/DIAMAP-Chapter-2.pdf
  • Kikutani, H; Yokota, A; Uchibayashi, N; Yukawa, K; Tanaka, T; Sugiyama, K; Barsumian, E. L; Suemura, M; Kishimoto, T (1989). "Structure and function of Fc epsilon receptor II (Fc epsilon RII/CD23): A point of contact between the effector phase of allergy and B cell differentiation". Ciba Foundation symposium. 147: 23–31, discussion 31–5. PMID 2695308.
  • Kikutani, Hitoshi; Yokota, Akira; Uchibayashi, Naoto; Yukawa, Kazunori; Tanaka, Tetsuji; Sugiyama, Kenji; Barsumian, Edward L; Suemura, Masaki; Kishimoto, Tadamitsu (2007). "Structure and Function of Fcε Receptor II (FcεRII/CD23): A Point of Contact Between the Effector Phase of Allergy and B Cell Differentiation". Ciba Foundation Symposium 147 - IgE, Mast Cells and the Allergic Response. Novartis Foundation Symposia. pp. 23–35. doi:10.1002/9780470513866.ch3. ISBN 978-0-470-51386-6.
  • Andralojc, K. M; Mercalli, A; Nowak, K. W; Albarello, L; Calcagno, R; Luzi, L; Bonifacio, E; Doglioni, C; Piemonti, L (2008). "Ghrelin-producing epsilon cells in the developing and adult human pancreas". Diabetologia. 52 (3): 486–93. doi:10.1007/s00125-008-1238-y. PMID 19096824.
  • Granata, R; Baragli, A; Settanni, F; Scarlatti, F; Ghigo, E (2010). "Unraveling the role of the ghrelin gene peptides in the endocrine pancreas". Journal of Molecular Endocrinology. 45 (3): 107–18. doi:10.1677/JME-10-0019. PMID 20595321.
  • http://www.copewithcytokines.de/cope.cgi?key=Epsilon%20cells
  • Thompson, H L; Metcalfe, D D; Kinet, J P (1990). "Early expression of high-affinity receptor for immunoglobulin E (Fc epsilon RI) during differentiation of mouse mast cells and human basophils". Journal of Clinical Investigation. 85 (4): 1227–33. doi:10.1172/JCI114557. PMC 296556. PMID 2138633.
  • http://www.biolcell.org/boc/098/0667/0980667.pdf%5Bdead+link%5D
  • http://www.cfsph.iastate.edu/Factsheets/pdfs/epsilon_toxin_clostridium.pdf
  • http://www.abcam.com/TCP1-epsilon-antibody-ab82778.pdf
  • https://web.archive.org/web/20070927093559/http://www.ihop-net.org/UniPub/iHOP/pm/10257219.html?pmid=14970313


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