Demethylrebeccamycin-D-glucose O-methyltransferase
| Demethylrebeccamycin-D-glucose O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.164 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Demethylrebeccamycin-D-glucose O-methyltransferase (EC 2.1.1.164, RebM) is an enzyme with systematic name S-adenosyl-L-methionine:demethylrebeccamycin-D-glucose O-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction
- 4'-demethylrebeccamycin + S-adenosyl-L-methionine rebeccamycin + S-adenosyl-L-homocysteine
Demethylrebeccamycin-D-glucose O-methyltransferase catalyses the last step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the Actinobacterium Lechevalieria aerocolonigenes.
References
- ↑ Zhang, C.; Albermann, C.; Fu, X.; Peters, N.R.; Chisholm, J.D.; Zhang, G.; Gilbert, E.J.; Wang, P.G.; Van Vranken, D.L.; Thorson, J.S. (2006). "RebG- and RebM-catalyzed indolocarbazole diversification". Chembiochem. 7 (5): 795–804. doi:10.1002/cbic.200500504. PMID 16575939.
- ↑ Singh, S.; McCoy, J.G.; Zhang, C.; Bingman, C.A.; Phillips, G.N.; Jr.; Thorson, J.S. (2008). "Structure and mechanism of the rebeccamycin sugar 4′-O-methyltransferase RebM". J. Biol. Chem. 283 (33): 22628–22636. doi:10.1074/jbc.M800503200. PMC 2504894. PMID 18502766.
External links
- Demethylrebeccamycin-D-glucose+O-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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