Demethylmenaquinone methyltransferase

Demethylmenaquinone methyltransferase
Identifiers
EC number 2.1.1.163
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Demethylmenaquinone methyltransferase (EC 2.1.1.163, S-adenosyl-L-methionine-DMK methyltransferase, demethylmenaquinone C-methylase, 2-heptaprenyl-1,4-naphthoquinone methyltransferase, 2-demethylmenaquinone methyltransferase, S-adenosyl-L-methionine:2-demethylmenaquinone methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:demethylmenaquinone methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

demethylmenaquinol + S-adenosyl-L-methionine menaquinol + S-adenosyl-L-homocysteine

The enzyme catalyses the last step in menaquinone biosynthesis.

References

  1. ↑ Koike-Takeshita A, Koyama T, Ogura K (May 1997). "Identification of a novel gene cluster participating in menaquinone (vitamin K2) biosynthesis. Cloning and sequence determination of the 2-heptaprenyl-1,4-naphthoquinone methyltransferase gene of Bacillus stearothermophilus". The Journal of Biological Chemistry. 272 (19): 12380–3. doi:10.1074/jbc.272.19.12380. PMID 9139683.
  2. ↑ Wissenbach U, Ternes D, Unden G (1992). "An Escherichia coli mutant containing only demethylmenaquinone, but no menaquinone: effects on fumarate, dimethylsulfoxide, trimethylamine N-oxide and nitrate respiration". Archives of Microbiology. 158 (1): 68–73. doi:10.1007/BF00249068. PMID 1444716.
  3. ↑ Catala F, Azerad R, Lederer E (1970). "[Properties of demethylmenaquinone C-methylase from Mycobacterium phlei]". Internationale Zeitschrift Fur Vitaminforschung. International Journal of Vitamin Research. Journal International De Vitaminologie. 40 (3): 363–73. PMID 5450997.
  4. ↑ Lee PT, Hsu AY, Ha HT, Clarke CF (March 1997). "A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene". Journal of Bacteriology. 179 (5): 1748–54. PMC 178890. PMID 9045837.
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