Cyclic-guanylate-specific phosphodiesterase

Cyclic-guanylate-specific phosphodiesterase
Identifiers
EC number 3.1.4.52
CAS number 338732-46-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Cyclic-guanylate-specific phosphodiesterase (EC 3.1.4.52, cyclic bis(3->5')diguanylate phosphodiesterase, c-di-GMP-specific phosphodiesterase, c-di-GMP phosphodiesterase, phosphodiesterase, phosphodiesterase A1, PDEA1, VieA) is an enzyme with systematic name cyclic bis(3->5')diguanylate 3-guanylylhydrolase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

cyclic di-3',5'-guanylate + H2O 5'-phosphoguanylyl(3'->5')guanosine

This enzyme requires Mg2+ or Mn2+ for activity. It is inhibited by Ca2+ and Zn2+.

References

  1. ↑ Chang, A.L.; Tuckerman, J.R.; Gonzalez, G.; Mayer, R.; Weinhouse, H.; Volman, G.; Amikam, D.; Benziman, M.; Gilles-Gonzalez, M.A. (2001). "Phosphodiesterase A1, a regulator of cellulose synthesis in Acetobacter xylinum, is a heme-based sensor". Biochemistry. 40 (12): 3420–3426. doi:10.1021/bi0100236. PMID 11297407.
  2. ↑ Christen, M.; Christen, B.; Folcher, M.; Schauerte, A.; Jenal, U. (2005). "Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP". J. Biol. Chem. 280 (35): 30829–30837. doi:10.1074/jbc.M504429200. PMID 15994307.
  3. ↑ Schmidt, A.J.; Ryjenkov, D.A.; Gomelsky, M. (2005). "The ubiquitous protein domain EAL is a cyclic diguanylate-specific phosphodiesterase: enzymatically active and inactive EAL domains". J. Bacteriol. 187 (14): 4774–4781. doi:10.1128/JB.187.14.4774-4781.2005. PMC 1169503. PMID 15995192.
  4. ↑ Tamayo, R.; Tischler, A.D.; Camilli, A. (2005). "The EAL domain protein VieA is a cyclic diguanylate phosphodiesterase". J. Biol. Chem. 280 (39): 33324–33330. doi:10.1074/jbc.M506500200. PMC 2776828. PMID 16081414.
  5. ↑ Chua SL, Liu Y, Yam JK, Tolker-Nielsen T, Kjelleberg S, Givskov M, Yang L (2014). "Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles". Nature Communications. 5: 4462. doi:10.1038/ncomms5462. PMID 25042103.
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