Calpain-3

Calpain-3
Identifiers
EC number 3.4.22.54
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Calpain-3 (EC 3.4.22.54, p94, calpain p94, CAPN3, muscle calpain, calpain 3, calcium-activated neutral proteinase 3, muscle-specific calcium-activated neutral protease 3, CANP 3, calpain L3) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Broad endopeptidase activity

This Ca2+ dependent enzyme is found in skeletal muscles.

See also

References

  1. ↑ Sorimachi H, Imajoh-Ohmi S, Emori Y, Kawasaki H, Ohno S, Minami Y, Suzuki K (November 1989). "Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle". The Journal of Biological Chemistry. 264 (33): 20106–11. PMID 2555341.
  2. ↑ Sorimachi H, Kinbara K, Kimura S, Takahashi M, Ishiura S, Sasagawa N, Sorimachi N, Shimada H, Tagawa K, Maruyama K (December 1995). "Muscle-specific calpain, p94, responsible for limb girdle muscular dystrophy type 2A, associates with connectin through IS2, a p94-specific sequence". The Journal of Biological Chemistry. 270 (52): 31158–62. doi:10.1074/jbc.270.52.31158. PMID 8537379.
  3. ↑ Rey MA, Davies PL (December 2002). "The protease core of the muscle-specific calpain, p94, undergoes Ca2+-dependent intramolecular autolysis". FEBS Letters. 532 (3): 401–6. doi:10.1016/s0014-5793(02)03722-5. PMID 12482600.
  4. ↑ García Díaz BE, Gauthier S, Davies PL (March 2006). "Ca2+ dependency of calpain 3 (p94) activation". Biochemistry. 45 (11): 3714–22. doi:10.1021/bi051917j. PMID 16533054.
  5. ↑ Ono Y, Torii F, Ojima K, Doi N, Yoshioka K, Kawabata Y, Labeit D, Labeit S, Suzuki K, Abe K, Maeda T, Sorimachi H (July 2006). "Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system". The Journal of Biological Chemistry. 281 (27): 18519–31. doi:10.1074/jbc.M601029200. PMID 16627476.
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