CAPN9

CAPN9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAPN9, GC36, nCL-4, calpain 9
External IDsMGI: 1920897 HomoloGene: 38208 GeneCards: CAPN9
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q42.2Start230,747,384 bp[1]
End230,802,003 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10753

73647

Ensembl

ENSG00000135773

ENSMUSG00000031981

UniProt

O14815

Q9D805

RefSeq (mRNA)

NM_006615
NM_016452
NM_001319676

NM_023709

RefSeq (protein)

NP_001306605
NP_006606
NP_057536

NP_076198

Location (UCSC)Chr 1: 230.75 – 230.8 MbChr 8: 124.58 – 124.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calpain-9 is a protein that in humans is encoded by the CAPN9 gene.[5][6][7]

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000135773 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031981 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Lee HJ, Sorimachi H, Jeong SY, Ishiura S, Suzuki K (May 1998). "Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract". Biol Chem. 379 (2): 175–184. doi:10.1515/bchm.1998.379.2.175. PMID 9524069.
  6. ↑ Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I (Jul 2000). "Isolation of two novel genes, down-regulated in gastric cancer". Jpn J Cancer Res. 91 (5): 459–63. doi:10.1111/j.1349-7006.2000.tb00967.x. PMID 10835488.
  7. 1 2 "Entrez Gene: CAPN9 calpain 9".

Further reading

  • Huang Y, Wang KK (2001). "The calpain family and human disease". Trends in Molecular Medicine. 7 (8): 355–362. doi:10.1016/S1471-4914(01)02049-4. PMID 11516996.
  • Suzuki K, Sorimachi H, Yoshizawa T, et al. (1996). "Calpain: novel family members, activation, and physiologic function". Biol. Chem. Hoppe-Seyler. 376 (9): 523–9. PMID 8561910.
  • Davis TL, Walker JR, Finerty PJ, et al. (2007). "The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition". J. Mol. Biol. 366 (1): 216–229. doi:10.1016/j.jmb.2006.11.037. PMID 17157313.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lee HJ, Tomioka S, Kinbara K, et al. (1999). "Characterization of a human digestive tract-specific calpain, nCL-4, expressed in the baculovirus system". Arch. Biochem. Biophys. 362 (1): 22–31. doi:10.1006/abbi.1998.1021. PMID 9917325.


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