Cathepsin K

CTSK
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCTSK, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD, cathepsin K
External IDsOMIM: 601105 MGI: 107823 HomoloGene: 68053 GeneCards: CTSK
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q21.3Start150,796,208 bp[1]
End150,808,323 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1513

13038

Ensembl

ENSG00000143387

ENSMUSG00000028111

UniProt

P43235

P55097

RefSeq (mRNA)

NM_000396

NM_007802

RefSeq (protein)

NP_000387

NP_031828

Location (UCSC)Chr 1: 150.8 – 150.81 MbChr 3: 95.5 – 95.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cathepsin K, abbreviated CTSK, is an enzyme that in humans is encoded by the CTSK gene.[5][6]

Function

The protein encoded by this gene is a lysosomal cysteine protease involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is expressed predominantly in osteoclasts.

Cathepsin K is a protease, which is defined by its high specificity for kinins, that is involved in bone resorption. The enzyme's ability to catabolize elastin, collagen, and gelatin allows it to break down bone and cartilage. This catabolic activity is also partially responsible for the loss of lung elasticity and recoil in emphysema. Cathepsin K inhibitors show great potential in the treatment of osteoporosis. Cathepsin K is degraded by Cathepsin S, called Controlled Cathepsin Cannibalism.

Cathepsin K expression is stimulated by inflammatory cytokines that are released after tissue injury.

Clinical significance

Cathepsin K is expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness.[7] Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.[8] Cathepsin K has also been found to be over-expressed in glioblastoma.[9]

That the expression of cathepsin K is characteristic for some cancers and not others has been documented.[10] Cathepsin K antibodies are marketed for research into expression of this enyzme by various cells.[11][12][13]

Merck had a cathepsin K inhibitor, odanacatib, in Phase III clinical trials for osteoporosis. In September, 2016, Merck announced they were discontinuing development of odanacatib after their own assessment of adverse events and an independent assessment showed increased risk of stroke.[14][15] Other cathepsin K inhbitors are in various stages of development.[16][17][18] Medivir has a cathepsin K inhibitor, MIV-711 (L-006235[19][20][21]), in Phase IIa clinical trial, as a disease modifying osteoarthritis drug, as of October 2017.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143387 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028111 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: CTSK cathepsin K".
  6. ↑ Inaoka T, Bilbe G, Ishibashi O, Tezuka K, Kumegawa M, Kokubo T (January 1995). "Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone". Biochem. Biophys. Res. Commun. 206 (1): 89–96. doi:10.1006/bbrc.1995.1013. PMID 7818555.
  7. ↑ Duong, Le T., Wesolowski, Gregg A., Leung, Patrick Oballa, Renata and Pickarski, Maureen (23 September 2014). ""Efficacy of a Cathepsin K Inhibitor in a Preclinical Model for Prevention and Treatment of Breast Cancer Bone Metastasis"". Molecular Cancer Therapeutics; 13(12);. American Association for Cancer Research. pp. 2898–909. Retrieved 2 October 2016.
  8. ↑ ""CTSK cathepsin K [ Homo sapiens (human) ]"". NCBI Gene. National Center for Biotechnology Information, U.S. National Library of Medicine. 4 September 2016. Retrieved 2 October 2016.
  9. ↑ Verbovšek, Urška, Motaln, Helena, Rotter, Ana, Atai, Nadia A., Gruden, Kristina, Van Noorden, Cornelis J.F., Lah, Tamara T. (30 October 2014). ""Expression Analysis of All Protease Genes Reveals Cathepsin K to Be Overexpressed in Glioblastoma"". PLOS ONE. LOCKSS. Retrieved 2 October 2016.
  10. ↑ Argani, Pedram; et al. (1 February 2013). ""A Broad Survey of Cathepsin K Immunoreactivity in Human Neoplasms"". American Journal of Clinical Pathology, Volume 139, Issue 2. Oxford Journals. pp. 151–159. Retrieved 2 October 2016.
  11. ↑ ""Cathepsin K Antibodies"". Novus Biologicals online catalog. Novus Biologicals, LLC. 2016. Retrieved 2 October 2016.
  12. ↑ ""Anti-Cathepsin K antibody (ab19027)"". Abcam plc online catalog. Abcam plc. 2016. Retrieved 2 October 2016.
  13. ↑ ""Anti-Cathepsin K Antibody (A5871)"". Antibodies.com online catalog. Antibodies.com Ltd. 2018. Retrieved 16 January 2018.
  14. ↑ Brömme, Dieter, Lecaille, Fabien (24 April 2009). ""Cathepsin K inhibitors for osteoporosis and potential off-target effects"". Expert Opinion on Investigational Drugs, Volume 18 2009 - Issue 5. Taylor & Francis Online. pp. 585–600. Retrieved 2 October 2016.
  15. ↑ ""Merck Provides Update on Odanacatib Development Program"". Merck Sharp & Dohme Corp. 2 September 2016. Retrieved 1 October 2016.
  16. ↑ Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H,. (2008). Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science, 319(5863), 624-627.
  17. ↑ Hussein, H., Ishihara, A., Menendez, M., & Bertone, A. (2014). Pharmacokinetics and bone resorption evaluation of a novel Cathepsin K inhibitor (VEL‐0230) in healthy adult horses. Journal of veterinary pharmacology and therapeutics.
  18. ↑ Ren, Zhong-Yuan; Machuca-Gayet, Irma; Domenget, Chantal; Buchet, Rene; Wu, Yuqing; Jurdic, Pierre; Mebarek, Saida (2015-07-13). "Azanitrile Cathepsin K Inhibitors: Effects on Cell Toxicity, Osteoblast-Induced Mineralization and Osteoclast-Mediated Bone Resorption". PLoS ONE. 10 (7). doi:10.1371/journal.pone.0132513. ISSN 1932-6203. PMC 4500499. PMID 26168340.
  19. ↑ "MIV-711 for the treatment of ostheoarthritis". www.medivir.se. Retrieved 2017-10-06.
  20. ↑ James J. Burston, Luting . Xu, Paul I. Mapp, Urszula Grabowska, Karin Tunblad, Erik Lindström, Victoria Chapman (April 2016). "THE CATHEPSIN K INHIBITOR L-006235 DEMONSTRATES BOTH DISEASE MODIFICATION AND ATTENUATION OF PAIN BEHAVIOUR IN THE IN THE MIA MODEL OF OSTEOARTHRITIS" (PDF). www.medivir.se.
  21. ↑ "Data monitoring committee gives "Go Ahead" in the MIV-711 osteoarthritis extension study" (PDF). mb.cision.com. 14 September 2017.

Further reading

  • Motyckova G, Fisher DE (2003). "Pycnodysostosis: role and regulation of cathepsin K in osteoclast function and human disease". Curr. Mol. Med. 2 (5): 407–21. doi:10.2174/1566524023362401. PMID 12125807.
  • Troen BR (2006). "The regulation of cathepsin K gene expression". Ann. N. Y. Acad. Sci. 1068: 165–72. doi:10.1196/annals.1346.018. PMID 16831915.
  • Del Nery E, Chagas JR, Juliano MA, et al. (1996). "Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments". Biochem. J. 312 (1): 233–8. PMC 1136249. PMID 7492318.
  • Brömme D, Okamoto K (1995). "Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution". Biol. Chem. Hoppe-Seyler. 376 (6): 379–84. doi:10.1515/bchm3.1995.376.6.379. PMID 7576232.
  • Gelb BD, Edelson JG, Desnick RJ (1995). "Linkage of pycnodysostosis to chromosome 1q21 by homozygosity mapping". Nat. Genet. 10 (2): 235–7. doi:10.1038/ng0695-235. PMID 7663521.
  • Polymeropoulos MH, Ortiz De Luna RI, Ide SE, et al. (1995). "The gene for pycnodysostosis maps to human chromosome 1cen-q21". Nat. Genet. 10 (2): 238–9. doi:10.1038/ng0695-238. PMID 7663522.
  • Shi GP, Chapman HA, Bhairi SM, et al. (1995). "Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2". FEBS Lett. 357 (2): 129–34. doi:10.1016/0014-5793(94)01349-6. PMID 7805878.
  • Inaoka T, Bilbe G, Ishibashi O, et al. (1995). "Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone". Biochem. Biophys. Res. Commun. 206 (1): 89–96. doi:10.1006/bbrc.1995.1013. PMID 7818555.
  • Velasco G, Ferrando AA, Puente XS, et al. (1994). "Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues". J. Biol. Chem. 269 (43): 27136–42. PMID 7929457.
  • Li YP, Alexander M, Wucherpfennig AL, et al. (1996). "Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas". J. Bone Miner. Res. 10 (8): 1197–202. doi:10.1002/jbmr.5650100809. PMID 8585423.
  • Bossard MJ, Tomaszek TA, Thompson SK, et al. (1996). "Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification". J. Biol. Chem. 271 (21): 12517–24. doi:10.1074/jbc.271.21.12517. PMID 8647860.
  • Gelb BD, Shi GP, Chapman HA, Desnick RJ (1996). "Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency". Science. 273 (5279): 1236–8. doi:10.1126/science.273.5279.1236. PMID 8703060.
  • Johnson MR, Polymeropoulos MH, Vos HL, et al. (1997). "A nonsense mutation in the cathepsin K gene observed in a family with pycnodysostosis". Genome Res. 6 (11): 1050–5. doi:10.1101/gr.6.11.1050. PMID 8938428.
  • Littlewood-Evans A, Kokubo T, Ishibashi O, et al. (1997). "Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry". Bone. 20 (2): 81–6. doi:10.1016/S8756-3282(96)00351-1. PMID 9028530.
  • McGrath ME, Klaus JL, Barnes MG, Brömme D (1997). "Crystal structure of human cathepsin K complexed with a potent inhibitor". Nat. Struct. Biol. 4 (2): 105–9. doi:10.1038/nsb0297-105. PMID 9033587.
  • Rood JA, Van Horn S, Drake FH, et al. (1997). "Genomic organization and chromosome localization of the human cathepsin K gene (CTSK)". Genomics. 41 (2): 169–76. doi:10.1006/geno.1997.4614. PMID 9143491.
  • Gelb BD, Shi GP, Heller M, et al. (1997). "Structure and chromosomal assignment of the human cathepsin K gene". Genomics. 41 (2): 258–62. doi:10.1006/geno.1997.4631. PMID 9143502.
  • Gomes RA, Juliano L, Chagas JR, Hial V (1997). "Characterization of kininogenase activity of an acidic proteinase isolated from human kidney". Can. J. Physiol. Pharmacol. 75 (6): 757–61. doi:10.1139/cjpp-75-6-757. PMID 9276160.
  • Thompson SK, Halbert SM, Bossard MJ, et al. (1998). "Design of potent and selective human cathepsin K inhibitors that span the active site". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14249–54. doi:10.1073/pnas.94.26.14249. PMC 24926. PMID 9405598.
  • Gelb BD, Willner JP, Dunn TM, et al. (1998). "Paternal uniparental disomy for chromosome 1 revealed by molecular analysis of a patient with pycnodysostosis". American Journal of Human Genetics. 62 (4): 848–54. doi:10.1086/301795. PMC 1377035. PMID 9529353.

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