CUL7

CUL7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCUL7, 3M1, KIAA0076, dJ20C7.5, cullin 7, CUL-7
External IDsMGI: 1913765 HomoloGene: 56683 GeneCards: CUL7
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.1Start43,037,617 bp[1]
End43,053,945 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9820

66515

Ensembl

ENSG00000044090

ENSMUSG00000038545

UniProt

Q14999

Q8VE73

RefSeq (mRNA)

NM_001168370
NM_014780

NM_025611

RefSeq (protein)

NP_001161842
NP_055595

NP_079887

Location (UCSC)Chr 6: 43.04 – 43.05 MbChr 17: 46.65 – 46.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cullin-7 is a RING-E3 ligase protein that in humans is encoded by the CUL7 gene.[5][6][7]

Clinical significance

It is associated with 3-M syndrome.

Interactions

CUL7 has been shown to interact with RBX1.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000044090 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038545 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 Dias DC, Dolios G, Wang R, Pan ZQ (Dec 2002). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc Natl Acad Sci U S A. 99 (26): 16601–6. doi:10.1073/pnas.252646399. PMC 139190. PMID 12481031.
  6. ↑ Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA (Aug 2003). "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis". Proc Natl Acad Sci U S A. 100 (17): 9855–60. doi:10.1073/pnas.1733908100. PMC 187864. PMID 12904573.
  7. ↑ "Entrez Gene: CUL7 cullin 7".

Further reading

  • Kim SS, Shago M, Kaustov L, et al. (2007). "CUL7 is a novel antiapoptotic oncogene". Cancer Res. 67 (20): 9616–22. doi:10.1158/0008-5472.CAN-07-0644. PMID 17942889.
  • Jung P, Verdoodt B, Bailey A, et al. (2007). "Induction of cullin 7 by DNA damage attenuates p53 function". Proc. Natl. Acad. Sci. U.S.A. 104 (27): 11388–93. doi:10.1073/pnas.0609467104. PMC 2040908. PMID 17586686.
  • Skaar JR, Florens L, Tsutsumi T, et al. (2007). "PARC and CUL7 form atypical cullin RING ligase complexes". Cancer Res. 67 (5): 2006–14. doi:10.1158/0008-5472.CAN-06-3241. PMID 17332328.
  • Kaustov L, Lukin J, Lemak A, et al. (2007). "The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53". J. Biol. Chem. 282 (15): 11300–7. doi:10.1074/jbc.M611297200. PMID 17298945.
  • Kasper JS, Arai T, DeCaprio JA (2006). "A novel p53-binding domain in CUL7". Biochem. Biophys. Res. Commun. 348 (1): 132–8. doi:10.1016/j.bbrc.2006.07.013. PMID 16875676.
  • Andrews P, He YJ, Xiong Y (2006). "Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function". Oncogene. 25 (33): 4534–48. doi:10.1038/sj.onc.1209490. PMID 16547496.
  • Huber C, Dias-Santagata D, Glaser A, et al. (2005). "Identification of mutations in CUL7 in 3-M syndrome". Nat. Genet. 37 (10): 1119–24. doi:10.1038/ng1628. PMID 16142236.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
  • Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
  • Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.


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