CCL12

Ccl12
Identifiers
Aliases	chemokine (C-C motif) ligand 12MCP-5Scya12
External IDs	HomoloGene: 2245 GeneCards:
Gene location (Human)
Chr.	Chromosome 11 (human)
End	82,103,400 bp
Gene ontology
Molecular function	• cytokine activity; • CCR2 chemokine receptor binding; • chemokine activity; • protein kinase activity; • phospholipase activator activity; • CCR chemokine receptor binding;
Cellular component	• extracellular region; • intracellular; • extracellular space; • cell;
Biological process	• negative regulation of neuron apoptotic process; • G-protein coupled receptor signaling pathway; • protein kinase B signaling; • monocyte chemotaxis; • astrocyte cell migration; • cytokine-mediated signaling pathway; • chemokine-mediated signaling pathway; • negative regulation of glial cell apoptotic process; • cellular response to tumor necrosis factor; • negative regulation of natural killer cell chemotaxis; • cellular response to organic cyclic compound; • neutrophil chemotaxis; • MAPK cascade; • chemotaxis; • positive regulation of GTPase activity; • positive regulation of calcium ion import; • macrophage chemotaxis; • cytoskeleton organization; • angiogenesis; • immune response; • cellular response to interleukin-1; • positive regulation of ERK1 and ERK2 cascade; • regulation of cell shape; • cellular response to interferon-gamma; • lymphocyte chemotaxis; • inflammatory response; • lipopolysaccharide-mediated signaling pathway; • regulation of receptor activity; • positive regulation of leukocyte migration; • negative regulation of leukocyte proliferation; • negative regulation of vascular endothelial cell proliferation; • negative regulation of G1/S transition of mitotic cell cycle; • positive regulation of endothelial cell apoptotic process; • calcium ion transport; • cellular calcium ion homeostasis; • exocytosis; • cell-cell signaling; • eosinophil chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	20293
	n/a
	ENSMUSG00000035352
	n/a
	Q62401
	n/a
	NM_011331
	n/a
	NP_035461
	n/a
	Wikidata
View/Edit Human

Chemokine (C-C motif) ligand 12 (CCL12) is a small cytokine belonging to the CC chemokine family that has been described in mice. It is also known as monocyte chemotactic protein 5 (MCP-5) and, due to its similarity with the human chemokine MCP-1, sometimes it is called MCP-1-related chemokine. CCL12 specifically attracts eosinophils, monocytes and lymphocytes.^[2] This chemokine is found predominantly in lymph nodes and thymus under normal conditions, and its expression can be hugely induced in macrophages.^[2]^[3] It is thought to coordinate cell movements during early allergic reactions, and immune response to pathogens. The gene for CCL12 is found in a cluster of CC chemokines on mouse chromosome 11.^[3]

References

↑ "Human PubMed Reference:".
1 2 Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J (1996). "Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation". J Exp Med. 184 (5): 1939–51. doi:10.1084/jem.184.5.1939. PMC 2192876. PMID 8920881.
1 2 Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A (1997). "Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1". J Exp Med. 185 (1): 99–109. doi:10.1084/jem.185.1.99. PMC 2196097. PMID 8996246.

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[1] "Human PubMed Reference:".

[jia-2] 1 2 Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J (1996). "Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation". J Exp Med. 184 (5): 1939–51. doi:10.1084/jem.184.5.1939. PMC 2192876. PMID 8920881.

[sarafi-3] 1 2 Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A (1997). "Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1". J Exp Med. 185 (1): 99–109. doi:10.1084/jem.185.1.99. PMC 2196097. PMID 8996246.