CXCL15

Cxcl15
Identifiers
Aliases	chemokine (C-X-C motif) ligand 15Il8Scyb15lungkineweche
External IDs	GeneCards:
Gene location (Human)
Chr.	Chromosome 5 (human)
End	90,803,067 bp
Gene ontology
Molecular function	• chemokine activity; • cytokine activity; • CXCR3 chemokine receptor binding;
Cellular component	• extracellular region; • extracellular space;
Biological process	• chemotaxis; • chemokine-mediated signaling pathway; • G-protein coupled receptor signaling pathway; • response to lipopolysaccharide; • inflammatory response; • regulation of cell proliferation; • immune response; • neutrophil chemotaxis; • positive regulation of leukocyte chemotaxis; • defense response; • T cell chemotaxis; • regulation of receptor activity; • haematopoiesis; • leukocyte chemotaxis; • antimicrobial humoral immune response mediated by antimicrobial peptide; • cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	20309
	n/a
	ENSMUSG00000029375
	n/a
	Q9WVL7
	n/a
	NM_011339
	n/a
	NP_035469
	n/a
	Wikidata
View/Edit Human

Chemokine (C-X-C motif) ligand 15 (CXCL15) is a small cytokine belonging to the CXC chemokine family that has been described in the mouse. This chemokine is also known under the name lungkine. CXCL15 is an ELR+ CXC chemokine (it contains the amino acid sequence E-L-R immediately before its CXC motif) that recruits neutrophils during inflammation of the lungs. It is highly abundant in epithelial cells of the lung,^[2] and can also be found in other mucosal organs such as the urogenital and gastrointestinal tracts, and in endocrine organs like the adrenal gland.^[3] The gene for CXCL15 is found on mouse chromosome 5.

References

↑ "Human PubMed Reference:".
↑ Rossi D, Hurst S, Xu Y, Wang W, Menon S, Coffman R, Zlotnik A (1999). "Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells". J Immunol. 162 (9): 5490–7. PMID 10228029.
↑ Schmitz J, McCracken V, Dimmitt R, Lorenz R (2007). "Expression of CXCL15 (Lungkine) in Murine Gastrointestinal, Urogenital, and Endocrine Organs". J Histochem Cytochem. 55 (5): 515–24. doi:10.1369/jhc.6A7121.2007. PMID 17242461.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] "Human PubMed Reference:".

[2] Rossi D, Hurst S, Xu Y, Wang W, Menon S, Coffman R, Zlotnik A (1999). "Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells". J Immunol. 162 (9): 5490–7. PMID 10228029.

[3] Schmitz J, McCracken V, Dimmitt R, Lorenz R (2007). "Expression of CXCL15 (Lungkine) in Murine Gastrointestinal, Urogenital, and Endocrine Organs". J Histochem Cytochem. 55 (5): 515–24. doi:10.1369/jhc.6A7121.2007. PMID 17242461.