cAd3-ZEBOV

CAd3-ZEBOV
Vaccine description
Target disease Ebola virus
Type Recombinant vector
Identifiers
ChemSpider
  • none

cAd3-ZEBOV (also known as the NIAID/GSK Ebola vaccine or cAd3-EBO Z) is an experimental vaccine for two ebolaviruses, Ebola virus and Sudan virus, developed by scientists at GlaxoSmithKline (GSK) and tested by National Institute of Allergy and Infectious Disease (NIAID).[1] This vaccine is derived from a chimpanzee adenovirus, Chimp Adenovirus type 3 (ChAd3), genetically engineered to express glycoproteins from the Zaire and Sudan species of ebolavirus to provoke an immune response against them. Simultaneous phase 1 trials of this vaccine commenced in September 2014, being administered to volunteers in Oxford and Bethesda.[2] During October the vaccine is being administered to a further group of volunteers in Mali. If this phase is completed successfully, the vaccine will be fast tracked for use in the Ebola virus epidemic in West Africa. In preparation for this, GSK is preparing a stockpile of 10,000 doses.[3][4]

First British trial

Following ten Americans who received the vaccine in a trial, Ruth Atkins (born 1966)[5] of Oxfordshire, a former nurse with the British National Health Service, was the first British volunteer to receive the experimental vaccine (on September 17, 2014) in a vaccine trial run by Oxford University researchers and funded by the Wellcome Trust and the UK government. This variant was only designed to protect against Ebola virus and not Sudan virus.[6]

See also

References

  1. ↑ Pavot, Vincent (1 December 2016). "Ebola virus vaccines: Where do we stand?". Clinical Immunology. 173: 44–49. doi:10.1016/j.clim.2016.10.016.
  2. ↑ "Experimental Ebola Vaccine Processed in Maryland". Drug Discov. Dev. Associated Press. 2 October 2014.
  3. ↑ "First British volunteer injected with trial Ebola vaccine in Oxford". Guardian. 17 September 2014. Retrieved 17 September 2014.
  4. ↑ "An Ebola vaccine was given to 10 volunteers, and there are 'no red flags' yet". Washington Post. 16 September 2014. Retrieved 17 September 2014.
  5. ↑ First volunteer receives new Ebola vaccine in UK trial
  6. ↑ First British volunteer injected with trial Ebola vaccine in Oxford, The Guardian, Wednesday 17 September 2014 12.01 EDT, accessed 09/17/2014

Further reading

  • Choi, Woo Young; Hong, Kee-Jong; Hong, Joo Eun; Lee, Won-Ja (1 January 2015). "Progress of vaccine and drug development for Ebola preparedness". Clinical and Experimental Vaccine Research. 4 (1): 11–16. doi:10.7774/cevr.2015.4.1.11. ISSN 2287-3651. PMC 4313103. PMID 25648233.
  • De Santis, Olga; Audran, Régine; Pothin, Emilie; Warpelin-Decrausaz, Loane; Vallotton, Laure; Wuerzner, Grégoire; Cochet, Camille; Estoppey, Daniel; Steiner-Monard, Viviane; Lonchampt, Sophie; Thierry, Anne-Christine; Mayor, Carole; Bailer, Robert T.; Mbaya, Olivier Tshiani; Zhou, Yan; Ploquin, Aurélie; Sullivan, Nancy J.; Graham, Barney S.; Roman, François; De Ryck, Iris; Ballou, W. Ripley; Kieny, Marie Paule; Moorthy, Vasee; Spertini, François; Genton, Blaise (1 March 2016). "Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled, dose-finding, phase 1/2a study". The Lancet. Infectious Diseases. 16 (3): 311–320. doi:10.1016/S1473-3099(15)00486-7. PMID 26725450.
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