23S rRNA (uracil747-C5)-methyltransferase

23S rRNA (uracil747-C5)-methyltransferase
Identifiers
EC number 2.1.1.189
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

23S rRNA (uracil747-C5)-methyltransferase (EC 2.1.1.189, YbjF, RumB, RNA uridine methyltransferase B) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (uracil747-C5)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + uracil747 in 23S rRNA S-adenosyl-L-homocysteine + 5-methyluracil747 in 23S rRNA

The enzyme specifically methylates uracil747 at C5 in 23S rRNA.

References

  1. Madsen, C.T.; Mengel-Jorgensen, J.; Kirpekar, F.; Douthwaite, S. (2003). "Identifying the methyltransferases for m5U747 and m5U1939 in 23S rRNA using MALDI mass spectrometry". Nucleic Acids Res. 31: 4738–4746. doi:10.1093/nar/gkg657. PMC 169892. PMID 12907714.
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