23S rRNA (cytosine1962-C5)-methyltransferase

23S rRNA (cytosine1962-C5)-methyltransferase
Identifiers
EC number 2.1.1.191
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

23S rRNA (cytosine1962-C5)-methyltransferase (EC 2.1.1.191, RlmI, rRNA large subunit methyltransferase I, YccW) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (cytosine1962-C5)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytosine1962 in 23S rRNA S-adenosyl-L-homocysteine + 5-methylcytosine1962 in 23S rRNA

The enzyme specifically methylates cytosine1962 at C5 in 23S rRNA.

References

  1. ↑ Purta, E.; O'Connor, M.; Bujnicki, J.M.; Douthwaite, S. (2008). "YccW is the m5C methyltransferase specific for 23S rRNA nucleotide 1962". J. Mol. Biol. 383 (3): 641–651. doi:10.1016/j.jmb.2008.08.061. PMID 18786544.
  2. ↑ Sunita, S.; Tkaczuk, K.L.; Purta, E.; Kasprzak, J.M.; Douthwaite, S.; Bujnicki, J.M.; Sivaraman, J. (2008). "Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes". J. Mol. Biol. 383 (3): 652–666. doi:10.1016/j.jmb.2008.08.062. PMID 18789337.
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