2-Polyprenyl-6-hydroxyphenyl methylase

2-polyprenyl-6-hydroxyphenyl methylase
Identifiers
EC number 2.1.1.222
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

2-polyprenyl-6-hydroxyphenyl methylase (EC 2.1.1.222, ubiG (gene), ubiG methyltransferase, 2-octaprenyl-6-hydroxyphenyl methylase) is an enzyme with systematic name S-adenosyl-L-methionine:3-(all-trans-polyprenyl)benzene-1,2-diol 2-O-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol

UbiG catalyses both methylation steps in ubiquinone biosynthesis in Escherichia coli.

References

  1. ↑ Poon WW, Barkovich RJ, Hsu AY, Frankel A, Lee PT, Shepherd JN, Myles DC, Clarke CF (July 1999). "Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis". The Journal of Biological Chemistry. 274 (31): 21665–72. doi:10.1074/jbc.274.31.21665. PMID 10419476.
  2. ↑ Hsu AY, Poon WW, Shepherd JA, Myles DC, Clarke CF (July 1996). "Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis". Biochemistry. 35 (30): 9797–806. doi:10.1021/bi9602932. PMID 8703953.
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