WNT5B

Protein Wnt-5b is a protein that in humans is encoded by the WNT5B gene.[5][6]

WNT5B
Identifiers
AliasesWNT5B, Wnt family member 5B
External IDsOMIM: 606361 MGI: 98959 HomoloGene: 22530 GeneCards: WNT5B
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12p13.33Start1,529,891 bp[1]
End1,647,243 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

81029

22419

Ensembl

ENSG00000111186

ENSMUSG00000030170

UniProt

Q9H1J7

P22726

RefSeq (mRNA)

NM_030775
NM_032642

NM_001271757
NM_001271758
NM_009525

RefSeq (protein)

NP_110402
NP_116031

NP_001258686
NP_001258687
NP_033551

Location (UCSC)Chr 12: 1.53 – 1.65 MbChr 6: 119.43 – 119.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The WNT gene family consists of structurally-related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates two transcript variants.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000111186 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030170 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Saitoh T, Katoh M (Jul 2001). "Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region". Int J Oncol. 19 (2): 347–51. doi:10.3892/ijo.19.2.347. PMID 11445850.
  6. "Entrez Gene: WNT5B wingless-type MMTV integration site family, member 5B".

Further reading



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