WNT2

WNT2
Identifiers
Aliases	WNT2, INT1L1, IRP, Wnt family member 2
External IDs	OMIM: 147870 MGI: 98954 HomoloGene: 20719 GeneCards: WNT2
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	117,323,152 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	18,030,585 bp[2]
Gene ontology
Molecular function	• GO:0005110 frizzled binding; • receptor binding; • cytokine activity; • GO:0001948 protein binding; • receptor ligand activity;
Cellular component	• cytoplasm; • extracellular matrix; • Wnt signalosome; • cell membrane; • extracellular region; • extracellular; • extrinsic component of external side of plasma membrane; • collagen-containing extracellular matrix;
Biological process	• positive regulation of mesenchymal cell proliferation; • positive regulation of cardiac muscle cell proliferation; • positive regulation of endothelial cell proliferation; • mammary gland epithelium development; • lung development; • cell-cell signaling; • multicellular organism development; • positive regulation of sequence-specific DNA binding transcription factor activity; • neurogenesis; • lens development in camera-type eye; • cardiac epithelial to mesenchymal transition; • lung induction; • cellular response to retinoic acid; • iris morphogenesis; • cellular response to transforming growth factor beta stimulus; • positive regulation of epithelial cell proliferation involved in lung morphogenesis; • positive regulation of cell proliferation; • positive regulation of transcription from RNA polymerase II promoter; • cell fate commitment; • labyrinthine layer blood vessel development; • positive regulation of fibroblast proliferation; • atrial cardiac muscle tissue morphogenesis; • positive regulation of canonical Wnt signaling pathway; • canonical Wnt signaling pathway; • neuron differentiation; • midbrain dopaminergic neuron differentiation; • canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; • Wnt signaling pathway; • regulation of receptor activity; • cell proliferation in midbrain;
	Sources:Amigo / QuickGO
Orthologs
	7472
	22413
	ENSG00000105989
	ENSMUSG00000010797
	P09544
	P21552
	NM_003391
	NM_023653
	NP_003382
	NP_076142
	Wikidata
View/Edit Human	View/Edit Mouse

Wingless-type MMTV integration site family, member 2, also known as WNT2, is a human gene.[5][6]

This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes that encode secreted signaling proteins involved in the Wnt signaling pathway. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene.[5]

References

GRCh38: Ensembl release 89: ENSG00000105989 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000010797 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: WNT2 wingless-type MMTV integration site family, member 2".
Wainwright BJ, Scambler PJ, Stanier P, Watson EK, Bell G, Wicking C, Estivill X, Courtney M, Boue A, Pedersen PS (June 1988). "Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless". EMBO J. 7 (6): 1743–8. doi:10.1002/j.1460-2075.1988.tb03003.x. PMC 457162. PMID 2971536.

Katoh M (2003). "WNT2 and human gastrointestinal cancer (review)". Int. J. Mol. Med. 12 (5): 811–6. doi:10.3892/ijmm.12.5.811. PMID 14533014.
Li J, Nguyen L, Gleason C, et al. (2004). "Lack of evidence for an association between WNT2 and RELN polymorphisms and autism". Am. J. Med. Genet. B Neuropsychiatr. Genet. 126B (1): 51–7. doi:10.1002/ajmg.b.20122. PMID 15048648.
Pu P, Zhang Z, Kang C, et al. (2009). "Downregulation of Wnt2 and beta-catenin by siRNA suppresses malignant glioma cell growth". Cancer Gene Ther. 16 (4): 351–61. doi:10.1038/cgt.2008.78. PMID 18949017.
Kodo K, Nishizawa T, Furutani M, et al. (2009). "GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling". Proc. Natl. Acad. Sci. U.S.A. 106 (33): 13933–8. doi:10.1073/pnas.0904744106. PMC 2728998. PMID 19666519.
Clément G, Braunschweig R, Pasquier N, et al. (2006). "Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus". Oncogene. 25 (21): 3084–92. doi:10.1038/sj.onc.1209338. PMID 16407829.
Park JK, Song JH, He TC, et al. (2009). "Overexpression of Wnt-2 in colorectal cancers". Neoplasma. 56 (2): 119–23. doi:10.4149/neo_2009_02_119. PMID 19239325.
Flahaut M, Meier R, Coulon A, et al. (2009). "The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathway". Oncogene. 28 (23): 2245–56. doi:10.1038/onc.2009.80. PMID 19421142.
Liu ZL, Li Y, Kong QY, et al. (2008). "Immunohistochemical profiling of Wnt, NF-kappaB, Stat3 and Notch signaling in human epidermal tumors". J. Dermatol. Sci. 52 (2): 133–6. doi:10.1016/j.jdermsci.2008.06.011. PMID 18703315.
Kloth JN, Fleuren GJ, Oosting J, et al. (2005). "Substantial changes in gene expression of Wnt, MAPK and TNFalpha pathways induced by TGF-beta1 in cervical cancer cell lines". Carcinogenesis. 26 (9): 1493–502. doi:10.1093/carcin/bgi110. PMID 15878915.
Mazieres J, You L, He B, et al. (2005). "Wnt2 as a new therapeutic target in malignant pleural mesothelioma". Int. J. Cancer. 117 (2): 326–32. doi:10.1002/ijc.21160. PMID 15900580.
Wang HX, Tekpetey FR, Kidder GM (2009). "Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells". Mol. Hum. Reprod. 15 (1): 11–7. doi:10.1093/molehr/gan070. PMID 19038973.
Han JC, Zhang KL, Chen XY, et al. (2007). "Expression of seven gastric cancer-associated genes and its relevance for Wnt, NF-kappaB and Stat3 signaling". APMIS. 115 (12): 1331–43. doi:10.1111/j.1600-0643.2007.00695.x. PMID 18184402.
Planutis K, Planutiene M, Moyer MP, et al. (2007). "Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells". BMC Cell Biol. 8: 12. doi:10.1186/1471-2121-8-12. PMC 1847812. PMID 17386109.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Cheng XX, Wang ZC, Chen XY, et al. (2005). "Frequent loss of membranous E-cadherin in gastric cancers: A cross-talk with Wnt in determining the fate of beta-catenin". Clin. Exp. Metastasis. 22 (1): 85–93. doi:10.1007/s10585-005-4578-8. PMID 16132582.
Shi Y, He B, Kuchenbecker KM, et al. (2007). "Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells". Int. J. Cancer. 121 (6): 1175–81. doi:10.1002/ijc.22848. PMID 17534895.
Cheng XX, Wang ZC, Chen XY, et al. (2005). "Correlation of Wnt-2 expression and beta-catenin intracellular accumulation in Chinese gastric cancers: relevance with tumour dissemination". Cancer Lett. 223 (2): 339–47. doi:10.1016/j.canlet.2004.11.013. PMID 15896469.
Ma XR, Edmund Sim UH, Pauline B, et al. (2008). "Overexpression of WNT2 and TSG101 genes in colorectal carcinoma". Tropical Biomedicine. 25 (1): 46–57. PMID 18600204.
de Krom M, Staal WG, Ophoff RA, et al. (2009). "A common variant in DRD3 receptor is associated with autism spectrum disorder". Biol. Psychiatry. 65 (7): 625–30. doi:10.1016/j.biopsych.2008.09.035. PMID 19058789.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105989 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000010797 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: WNT2 wingless-type MMTV integration site family, member 2".

[pmid2971536-6] Wainwright BJ, Scambler PJ, Stanier P, Watson EK, Bell G, Wicking C, Estivill X, Courtney M, Boue A, Pedersen PS (June 1988). "Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless". EMBO J. 7 (6): 1743–8. doi:10.1002/j.1460-2075.1988.tb03003.x. PMC 457162. PMID 2971536.

Signaling pathway: Wnt signaling pathway
Ligand	WNT1 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B WNT10A WNT10B WNT11 WNT16
Receptor	Frizzled LRP5 LRP6
Second messenger	Dishevelled GSK-3 APC Beta-catenin

WNT2

References

Further reading