Pirlimycin

Pirlimycin hydrochloride belongs to the lincosamide class of antimicrobials. Under the trade name Pirsue,[1] it is used in the treatment of mastitis in cattle.

Pirlimycin
Clinical data
Routes of
administration
Intramammary
ATCvet code
  • QJ51FF90 (WHO)
Identifiers
CAS Number
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H31ClN2O5S
Molar mass410.95 g·mol−1
3D model (JSmol)
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Activity

Pirlimycin is active against Gram-positive bacteria, specifically Staphylococcus aureus and coagulase negative species of Staphylococcus and Streptococcus. It has no activity against Gram-negative bacteria.[2]

Mechanism of action

It is bacteriostatic and acts by inhibiting bacterial protein synthesis via binding with the 50S subunit of the ribosome.

References

  1. Pirsue Sterile Solution
  2. "USP: Pirlimycin" (PDF). Archived from the original (PDF) on 2009-05-09. Retrieved 2009-06-28.


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