Apramycin

Apramycin (also Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. It is produced by Streptomyces tenebrarius.[1]

Apramycin
Clinical data
AHFS/Drugs.comInternational Drug Names
ATCvet code
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.048.582
Chemical and physical data
FormulaC21H41N5O11
Molar mass539.583 g·mol−1
3D model (JSmol)
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Spectrum of bacterial susceptibility and resistance

Apramycin can be used to treat bacterial infections in animals caused by Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The following shows susceptibility data on medically significant organisms:

  • Escherichia coli - 1 μg/mL - >512 μg/mL (this large range may be due to resistant organisms, typical MIC values are likely in the range of 2 -8 μg/mL.
  • Klebsiella pneumoniae - 2 μg/mL - >256 μg/mL
  • Pseudomonas aeruginosa - 4 μg/mL[2]

References

  1. Ryden R, Moore BJ (November 1977). "The in vitro activity of apramycin, a new aminocyclitol antibiotic". The Journal of Antimicrobial Chemotherapy. 3 (6): 609–613. doi:10.1093/jac/3.6.609. PMID 340441.
  2. "Apramycin". KnowledgeBase: The Antimicrobial Index.
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