Osmosis Jones

Frank DeTorre is an unkempt and slovenly zookeeper at the Sucat Memorial Zoo in Rhode Island. Frank is also a widower. Depressed by the loss of his wife years earlier, he copes by eating unhealthy and not exercising, to the annoyance of his young daughter Shane. Inside his body, white blood cell Osmosis "Ozzy" Jones is a rebellious officer of the Frank PD, who was demoted to patrol duty in the mouth after an incident where he induced Frank to vomit against orders, resulting in Frank being fired from his previous job at a pea soup factory and banned from visiting Shane's school due to a restraining order filed by her science teacher, Mrs. Boyd.

Two years later, facing a serious challenge to his reelection prospects, Mayor Phlegmming doubles down on his junk food policies, ignoring their effect on Frank's health. This causes Frank to eat a boiled egg covered in filth, allowing Thrax, a deadly virus, to enter the throat. Unwilling to admit responsibility, Phlegmming instructs Frank to take a cold suppressant through brain signals. The suppressant, Drixenol "Drix" Koldreliff, proceeds to disinfect the throat, covering up any evidence of Thrax's arrival. To his displeasure, Ozzy is subsequently assigned to assist Drix in his investigation. Meanwhile, Thrax assumes leadership of a gang of sweat germs and launches an attack on the mucus dam in Frank's nose, nearly killing Drix before Ozzy rescues him. The two pay a visit to one of Ozzy's informants, who reveals Thrax's plan to pose as a mere cold virus as a cover for killing Frank with a high fever in order to become the next big virus in the medical records. Based on his information, Ozzy goes undercover at a nightclub intending to infiltrate Thrax's gang, only to be discovered and forced to call in Drix, who manages to destroy the club with a grenade. The explosion pops a zit on Frank's forehead during a meeting with Mrs. Boyd, ruining any chance for him to apologize. In response, Phlegmming closes the investigation, has Ozzy fired from the force, and orders Drix to leave the city.

Having survived the assault, Thrax eliminates his remaining henchmen and launches a one-man assault on the hypothalamus gland (the portion of the brain that controls body temperature), where he steals a DNA bead. He then abducts the Mayor's secretary, Leah Estrogen, and flees to the mouth to escape. His actions disable the body's ability to regulate temperature, causing the city to break out in flames and panic. As Frank is taken to the hospital in a fever coma, Ozzy and Drix reconcile and proceed to rescue Leah. They succeed, but Thrax is able to exit the mouth using pollen as a distraction. Ozzy pursues him to the surface of Shane's eye, and as they fight they both land on one of Shane's false eyelashes. As Thrax has Jones pinned down after Jones recovers the DNA bead, he gloats over how he will break his record by killing Shane as his next victim, but gets stuck in the false eyelash; Jones escapes at the last minute before the eyelash slides off and lands in a vessel of rubbing alcohol, where Thrax melts.

As Frank's temperature goes over 108 degrees, his heart begins to shut down and flatline. Riding one of Shane's tears, Ozzy reenters his body with the bead in hand and replaces the missing chromosome, reviving Frank from his momentary state of death. Having narrowly cheated death, Frank commits himself to living a healthier lifestyle and Ozzy and Drix are declared heroes, with Ozzy having been reinstated to the force with Drix as his new partner, at which point Ozzy also begins a relationship with Leah. Frank and Shane go hiking, as he attempts to live a healthier life. Phlegmming, meanwhile, is impeached from office due to his actions having nearly killed Frank and the City of Frank with him, resulting in his opponent Tom Colonic winning the election by a landslide and himself reduced to a custodian in the bowels, where he ejects himself accidentally by triggering Frank's flatulence.

• Bill Murray as Frank DeTorre; the animated part of the film takes place inside his body, which is referred to by the cells as "the City of Frank"
• Elena Franklin as Shane DeTorre, Frank's 10-year-old daughter
• Molly Shannon as Mrs. Boyd, Shane's science and P.E. teacher
• Chris Elliott as Bob DeTorre, Frank's brother and Shane's uncle

Osmosis Jones went through development hell during production. The animated sequences, directed by Tom Sito and Piet Kroon, went into production as planned, but acquiring both a director and a star actor for the live-action sequences took a considerable amount of time, until Bill Murray was cast as the main character of Frank, and Peter and Bobby Farrelly stepped in to direct the live-action sequences. As part of their contract, the Farrelly brothers are credited as the primary directors of the film, although they did no supervision of the animated portions of the film. Will Smith was interested in the part of Ozzy, but in the end his schedule would not permit it.

Osmosis Jones was originally rated PG-13 by the MPAA for "crude language" and "bodily humor" in 2000. However, Warner Bros. edited the film to make it family-friendly; and in 2001 when it was released, the film was re-rated PG on appeal for "bodily humor".

A soundtrack containing hip hop and R&B music as well as "Torian and Andrew's Babblin'" was released on August 7, 2001 by Atlantic Records. The soundtrack failed to chart on the Billboard 200, but Trick Daddy's single "Take It to da House" managed to make it to 88 on the Billboard Hot 100 singles chart.

• Once Upon a Time... Life, an animated series with similar anthropomorphic representations of cells and germs.
• Ozzy & Drix, an animated series that serves as a continuation of the film.
• Inside Out, a Pixar computer-animated film that is also set inside the human body.
• Cells at Work!, a Japanese manga/anime series with a similar premise.
• Inner Workings, a Disney short film that is set in the human body.

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• Osmosis Jones on IMDb
• Osmosis Jones at The Big Cartoon DataBase