mir-764 microRNA precursor family

In molecular biology mir-764 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

mir-764
Identifiers
Symbolmir-764
RfamRF01920
miRBase familyMIPF0000707
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

Osteoblast Differentiation

Expression of the mature miR-764-5p sequence is upregulated during osteoblast differentiation in both skull-specific calvarial and osteoblast progenitor cells. The channel-forming integral protein, CHIP, is regulated by miR-764-5p at its 3'UTR, and there is negative correlation between expression of the two. Increased CHIP levels are observed with inhibition of miR-764-5p, whilst enhanced miR-764-3p expression sees decreased CHIP levels.[1] The differentiation fate of osteoblast progenitor cells is altered by impaired miR-764-3p levels due to CHIP. Osteoblast differentiation from progenitor cells has been shown to be positively regulated by repressed CHIP translation.

See also

References
  1. Guo J, Ren F, Wang Y, Li S, Gao Z, Wang X, et al. (2012). "miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression". J Bone Miner Res. 27 (7): 1607–18. doi:10.1002/jbmr.1597. PMID 22407479.

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