mir-160 microRNA precursor family

In molecular biology, mir-160 is a microRNA that has been predicted or experimentally confirmed in a range of plant species including Arabidopsis thaliana (mouse-ear cress) and Oryza sativa (rice).[1] miR-160 is predicted to bind complementary sites in the untranslated regions of auxin response factor genes to regulate their expression.[2] The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequence is excised from the 5' arm of the hairpin.

mir-160 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-160
Identifiers
Symbolmir-160
RfamRF00247
miRBaseMI0000190
miRBase familyMIPF0000032
Other data
RNA typeGene; miRNA
Domain(s)Eukaryota
GO0035195 0035068
SO0001244
PDB structuresPDBe

Specifically, 3 of A. thaliana's 23 auxin-response factor genes are thought to be post-transcriptionally regulated by mir-160.[3][4] When one of these targets (ARF17) is manipulated to become miRNA-resistant, several developmental defects can be observed in the host plant.[3] This experiment has been repeated with another mir-160 target, ARF10, and results highlighted a regulatory role in post-embryonic development and seed germination.[5]

References
  1. "miRNA gene family: MIR160". mirBASE. University of Manchester. Archived from the original on 15 July 2012. Retrieved 5 September 2011.
  2. Rhoades MW, Reinhart BJ, Lim LP, Burge CB, Bartel B, Bartel DP (August 2002). "Prediction of plant microRNA targets". Cell. 110 (4): 513–20. doi:10.1016/S0092-8674(02)00863-2. PMID 12202040.
  3. Mallory AC, Bartel DP, Bartel B (May 2005). "MicroRNA-directed regulation of Arabidopsis AUXIN RESPONSE FACTOR17 is essential for proper development and modulates expression of early auxin response genes". The Plant Cell. 17 (5): 1360–75. doi:10.1105/tpc.105.031716. PMC 1091760. PMID 15829600.
  4. Liu X, Huang J, Wang Y, Khanna K, Xie Z, Owen HA, Zhao D (May 2010). "The role of floral organs in carpels, an Arabidopsis loss-of-function mutation in MicroRNA160a, in organogenesis and the mechanism regulating its expression". The Plant Journal. 62 (3): 416–28. doi:10.1111/j.1365-313X.2010.04164.x. PMID 20136729.
  5. Liu PP, Montgomery TA, Fahlgren N, Kasschau KD, Nonogaki H, Carrington JC (October 2007). "Repression of AUXIN RESPONSE FACTOR10 by microRNA160 is critical for seed germination and post-germination stages". The Plant Journal. 52 (1): 133–46. doi:10.1111/j.1365-313X.2007.03218.x. PMID 17672844.

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