mir-46/mir-47/mir-281 microRNA precursor family

In molecular biology, mir-46 (MI0000017) and mir-47 (MI0000018) are microRNA expressed in C. elegans from related hairpin precursor sequences.[1] The predicted hairpin precursor sequences for Drosophila mir-281 (MI0000366, MI0000370)[2][3] are also related and, hence, belong to this family. The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequences are expressed from the 3' arms of the hairpin precursors.

mir-46/mir-47/mir-281 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-46
Identifiers
Symbolmir-46
RfamRF00249
miRBaseMI0000017
miRBase familyMIPF0000087
Other data
RNA typeGene; miRNA
Domain(s)Eukaryota
GO0035195 0035068
SO0001244
PDB structuresPDBe

References
  1. Lau NC, Lim LP, Weinstein EG, Bartel DP (October 2001). "An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans". Science. 294 (5543): 858–62. doi:10.1126/science.1065062. PMID 11679671.
  2. Lai EC, Tomancak P, Williams RW, Rubin GM (2003). "Computational identification of Drosophila microRNA genes". Genome Biology. 4 (7): R42. doi:10.1186/gb-2003-4-7-r42. PMC 193629. PMID 12844358.
  3. Aravin AA, Lagos-Quintana M, Yalcin A, Zavolan M, Marks D, Snyder B, Gaasterland T, Meyer J, Tuschl T (August 2003). "The small RNA profile during Drosophila melanogaster development". Developmental Cell. 5 (2): 337–50. doi:10.1016/S1534-5807(03)00228-4. hdl:11858/00-001M-0000-0010-94E8-6. PMID 12919683.

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