Deoxycytidine

Deoxycytidine
Names
	Other names 2′-Deoxycytidine
Identifiers
CAS Number	951-77-9 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:15698 ;
ChEMBL	ChEMBL66115 ;
ChemSpider	13117 ;
ECHA InfoCard	100.012.231
MeSH	Deoxycytidine
PubChem CID	637;
UNII	0W860991D6 ;
CompTox Dashboard (EPA)	DTXSID70883620 ;
	InChI InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 Key: CKTSBUTUHBMZGZ-SHYZEUOFSA-N ; InChI=1/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 Key: CKTSBUTUHBMZGZ-SHYZEUOFBO;
	SMILES c1cn(c(=O)nc1N)[C@H]2C[C@@H]([C@H](O2)CO)O;
Properties
Chemical formula	C9H13N3O4
Molar mass	227.217
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Deoxycytidine is a deoxyribonucleoside, a component of deoxyribonucleic acid. It is similar to the ribonucleoside cytidine, but with one hydroxyl group removed from the 2' position.

Can be phosphorylated at C-5 by Deoxycytidine kinase converting it to a thiamine nucleotide, a DNA precursor.[1]

It can also be used as a precursor for (5-aza-2′-Deoxycytidine) a treatment for MDS patients. This compound can slows the cell cycle by interfering with the methylation of the P15/INK4B gene, increasing the expression P15/INK4B protein. which subdues the transformation of MDS to leukemia.[2]

References

Staub M, Eriksson S (2006). "The Role of Deoxycytidine Kinase in DNA Synthesis and Nucleoside Analog Activation". In Peters GJ (ed.). Deoxynucleoside Analogs In Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. pp. 29–52. doi:10.1007/978-1-59745-148-2_2. ISBN 978-1-59745-148-2.
Kim KW, Roh JK, Wee HJ, Kim C (2016). "Molecular Targeted Anticancer Drugs". In Kim KW, Roh JK, Wee HJ, Kim C (eds.). Cancer Drug Discovery: Science and History. Springer Netherlands. pp. 175–238. doi:10.1007/978-94-024-0844-7_9. ISBN 978-94-024-0844-7.

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[1] Staub M, Eriksson S (2006). "The Role of Deoxycytidine Kinase in DNA Synthesis and Nucleoside Analog Activation". In Peters GJ (ed.). Deoxynucleoside Analogs In Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. pp. 29–52. doi:10.1007/978-1-59745-148-2_2. ISBN 978-1-59745-148-2.

[2] Kim KW, Roh JK, Wee HJ, Kim C (2016). "Molecular Targeted Anticancer Drugs". In Kim KW, Roh JK, Wee HJ, Kim C (eds.). Cancer Drug Discovery: Science and History. Springer Netherlands. pp. 175–238. doi:10.1007/978-94-024-0844-7_9. ISBN 978-94-024-0844-7.