GNAZ

Guanine nucleotide-binding protein G(z) subunit alpha is a protein that in humans is encoded by the GNAZ gene.[5][6]

GNAZ
Identifiers
AliasesGNAZ, G protein subunit alpha z, gz-alpha
External IDsOMIM: 139160 MGI: 95780 HomoloGene: 22574 GeneCards: GNAZ
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q11.22-q11.23Start23,070,519 bp[1]
End23,125,032 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2781

14687

Ensembl

ENSG00000128266

ENSMUSG00000040009

UniProt

P19086

O70443

RefSeq (mRNA)

NM_002073

NM_010311
NM_001358848

RefSeq (protein)

NP_002064

NP_034441
NP_001345777

Location (UCSC)Chr 22: 23.07 – 23.13 MbChr 10: 74.97 – 75.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systems. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids.[6]

Interactions

GNAZ has been shown to interact with EYA2,[7] RGS20[8][9] and RGS19.[7][10]

References

  1. GRCh38: Ensembl release 89: ENSG00000128266 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040009 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Matsuoka M, Itoh H, Kaziro Y (September 1990). "Characterization of the human gene for Gx alpha, a pertussis toxin-insensitive regulatory GTP-binding protein". J. Biol. Chem. 265 (22): 13215–20. PMID 2115889.
  6. "Entrez Gene: GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide".
  7. Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR (October 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. 275 (41): 32129–34. doi:10.1074/jbc.M004577200. PMID 10906137.
  8. Nagahama M, Usui S, Shinohara T, Yamaguchi T, Tani K, Tagaya M (December 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus". J. Cell Sci. 115 (Pt 23): 4483–93. doi:10.1242/jcs.00093. PMID 12414994.
  9. Glick JL, Meigs TE, Miron A, Casey PJ (October 1998). "RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha". J. Biol. Chem. 273 (40): 26008–13. doi:10.1074/jbc.273.40.26008. PMID 9748279.
  10. De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (December 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788.

Further reading


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