Cyclin-dependent kinase inhibitor protein

A cyclin-dependent kinase inhibitor protein is a protein which inhibits the enzyme cyclin-dependent kinase (CDK). Several function as tumor suppressor proteins. Cell cycle progression is delayed or stopped by cyclin-dependent kinase inhibitors, abbreviated CDIs, CKIs or CDKIs. CDIs are involved in cell cycle arrest at the G1 phase.

This article is about the cell cycle protein. For the medical therapy, see CDK inhibitor.
Cyclin-dependent kinase inhibitor
Structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.[1]
Identifiers
SymbolCDI
PfamPF02234
InterProIPR003175
SCOPe1jsu / SUPFAM

Seven cyclin-dependent kinase inhibitor proteins have thus far been identified. They are named by the small letter "p" followed by their molecular weight in kilodaltons. They are p15, p16, p18, p19, p21, p27, and p57.

Associated gene and target
Protein Gene Target
p16CDKN2ACyclin-dependent kinase 4, Cyclin-dependent kinase 6
p15CDKN2BCyclin-dependent kinase 4
p18CDKN2CCyclin-dependent kinase 4, Cyclin-dependent kinase 6
p19CDKN2DCyclin-dependent kinase 4, Cyclin-dependent kinase 6
p21 / WAF1CDKN1A[2]Cyclin E1/Cyclin-dependent kinase 2
p27CDKN1BCyclin D3/Cyclin-dependent kinase 4, Cyclin E1/Cyclin-dependent kinase 2
p57CDKN1CCyclin E1/Cyclin-dependent kinase 2
CDKN3Cyclin-dependent kinase 2

References
  1. Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP (July 1996). "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex". Nature. 382 (6589): 325–31. doi:10.1038/382325a0. PMID 8684460.
  2. Hoshino R, Chatani Y, Yamori T, Tsuruo T, Oka H, Yoshida O, Shimada Y, Ari-i S, Wada H, Fujimoto J, Kohno M (January 1999). "Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors". Oncogene. 18 (3): 813–22. doi:10.1038/sj.onc.1202367. PMID 9989833.


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