ROCK2

ROCK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4L6Q, 4WOT
Identifiers
Aliases	ROCK2, ROCK-II, Rho associated coiled-coil containing protein kinase 2
External IDs	OMIM: 604002 MGI: 107926 HomoloGene: 21010 GeneCards: ROCK2
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	11,348,330 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	16,987,823 bp[2]
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • protein kinase activity; • structural molecule activity; • metal ion binding; • kinase activity; • protein serine/threonine kinase activity; • GO:0001948 protein binding; • Rho GTPase binding; • ATP binding; • Rho-dependent protein serine/threonine kinase activity; • RNA binding; • tau protein binding; • tau-protein kinase activity; • GTP-Rho binding;
Cellular component	• cytoplasm; • centrosome; • membrane; • cell membrane; • microtubule organizing center; • cytoplasmic ribonucleoprotein granule; • cytoskeleton; • cell nucleus; • cytosol; • intracellular;
Biological process	• smooth muscle contraction; • positive regulation of protein phosphorylation; • intracellular signal transduction; • regulation of actin cytoskeleton organization; • centrosome duplication; • phosphorylation; • rhythmic process; • ephrin receptor signaling pathway; • cellular response to testosterone stimulus; • cytokinesis; • positive regulation of centrosome duplication; • regulation of stress fiber assembly; • regulation of cell motility; • positive regulation of endothelial cell migration; • protein phosphorylation; • negative regulation of bicellular tight junction assembly; • vascular endothelial growth factor receptor signaling pathway; • positive regulation of gene expression; • regulation of cell adhesion; • regulation of circadian rhythm; • Rho protein signal transduction; • regulation of focal adhesion assembly; • negative regulation of angiogenesis; • regulation of keratinocyte differentiation; • negative regulation of myosin-light-chain-phosphatase activity; • I-kappaB kinase/NF-kappaB signaling; • regulation of establishment of cell polarity; • cortical actin cytoskeleton organization; • regulation of establishment of endothelial barrier; • actin cytoskeleton organization; • protein localization to plasma membrane; • G-protein coupled receptor signaling pathway; • aortic valve morphogenesis; • positive regulation of cardiac muscle hypertrophy; • peptidyl-serine phosphorylation; • peptidyl-threonine phosphorylation; • positive regulation of cell migration; • positive regulation of connective tissue growth factor production; • positive regulation of MAPK cascade; • regulation of protein metabolic process; • positive regulation of stress fiber assembly; • negative regulation of biomineral tissue development; • response to transforming growth factor beta; • positive regulation of fibroblast growth factor production; • regulation of angiotensin-activated signaling pathway; • negative regulation of protein localization to lysosome; • positive regulation of amyloid-beta formation; • positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; • positive regulation of protein localization to early endosome; • positive regulation of amyloid precursor protein catabolic process; • positive regulation of connective tissue replacement; • response to angiotensin; • response to ischemia; • negative regulation of gene expression; • regulation of neurological system process; • negative regulation of nitric oxide biosynthetic process; • mRNA destabilization; • regulation of blood vessel diameter; • regulation of cellular response to hypoxia; • cellular response to acetylcholine; • mitotic cytokinesis; • actomyosin structure organization; • embryonic morphogenesis; • regulation of cell junction assembly;
	Sources:Amigo / QuickGO
Orthologs
	9475
	19878
	ENSG00000134318
	ENSMUSG00000020580
	O75116
	P70336
	NM_004850; NM_001321643
	NM_009072
	NP_001308572; NP_004841
	NP_033098
	Wikidata
View/Edit Human	View/Edit Mouse

Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. [5]Fasudil is an inhibitor of ROCK protein.

Function

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

References

GRCh38: Ensembl release 89: ENSG00000134318 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020580 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Rho associated coiled-coil containing protein kinase 2". Retrieved 2016-04-21.

External links

Overview of all the structural information available in the PDB for UniProt: O75116 (Human Rho-associated protein kinase 2 (ROCK2)) at the PDBe-KB.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134318 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020580 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Rho associated coiled-coil containing protein kinase 2". Retrieved 2016-04-21.

ROCK2

Function

References

Further reading

External links