CYP305M2
CYP305M2 (formerly called LM16181) is a cytochrome P450 enzyme found in migratory locust (Locusta migratoria) that catalyzes the key step of biosynthesis of phenylacetonitrile (PAN).[1][2] PAN in turn is used as a aposematic chemical defense against predators.
Biosynthesis of phenylacetonitrile catalyzed by CYP305M2 and subsequent decomposition to benzaldehyde and cyanide
| Identifiers | |||||||
|---|---|---|---|---|---|---|---|
| Organism | |||||||
| Symbol | CYP305M2 | ||||||
| UniProt | A0A410UD22 | ||||||
| Other data | |||||||
| EC number | 1.14.-.- | ||||||
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References
- Wei J, Shao W, Cao M, Ge J, Yang P, Chen L, Wang X, Kang L (January 2019). "Phenylacetonitrile in locusts facilitates an antipredator defense by acting as an olfactory aposematic signal and cyanide precursor". Science Advances. 5 (1): eaav5495. doi:10.1126/sciadv.aav5495. PMC 6357733. PMID 30746481.
- "Cytochrome P450 [Locusta migratoria]". NCBI Protein. National Center for Biotechnology Information, U.S. National Library of Medicine.
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