2-Hydroxy-1,4-benzoxazin-3-one monooxygenase

2-Hydroxy-1,4-benzoxazin-3-one monooxygenase (EC 1.14.13.140, BX5 (gene), CYP71C3 (gene)) is an enzyme with systematic name 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one,NAD(P)H:oxygen oxidoreductase (N-hydroxylating).[1][2] This enzyme catalyses the following chemical reaction

2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)H + H+ + O2 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O
2-Hydroxy-1,4-benzoxazin-3-one monooxygenase
Identifiers
EC number1.14.13.140
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

2-Hydroxy-1,4-benzoxazin-3-one monooxygenase is involved in the biosynthesis of protective and allelopathic benzoxazinoids in some plants.

References

  1. Bailey BA, Larson RL (March 1991). "Maize microsomal benzoxazinone N-monooxygenase". Plant Physiology. 95 (3): 792–6. doi:10.1104/pp.95.3.792. PMC 1077607. PMID 16668055.
  2. Glawischnig E, Grün S, Frey M, Gierl A (March 1999). "Cytochrome P450 monooxygenases of DIBOA biosynthesis: specificity and conservation among grasses". Phytochemistry. 50 (6): 925–30. doi:10.1016/s0031-9422(98)00318-5. PMID 10385992.
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