Zofenopril

Zofenopril
Clinical data
Trade names Zocardis (RU)
AHFS/Drugs.com International Drug Names
Routes of
administration		 Oral
ATC code
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
Formula C22H23NO4S2
Molar mass 429.552 g/mol
3D model (JSmol)
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Zofenopril (INN) is a medication that protects the heart and helps reduce high blood pressure. It is an angiotensin-converting enzyme (ACE) inhibitor.[1]

In small studies, zofenopril appeared significantly more effective in reducing hypertension than two older antihypertensive drugs, atenolol and enalapril, and was associated with fewer adverse effects.[2][3]

Zofenopril is a prodrug with zofenoprilat as the active metabolite.[4]

Zofenoprilat — the active metabolite of zofenopril

References

  1. ↑ Ambrosioni E (2007). "Defining the role of zofenopril in the management of hypertension and ischemic heart disorders". Am J Cardiovasc Drugs. 7 (1): 17–24. doi:10.2165/00129784-200707010-00002. PMID 17355163.
  2. ↑ Nilsson P (October 2007). "Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension". Blood Press Suppl. 2: 25–30. PMID 18046976.
  3. ↑ Mallion JM (October 2007). "An evaluation of the initial and long-term antihypertensive efficacy of zofenopril compared with enalapril in mild to moderate hypertension". Blood Press Suppl. 2: 13–8. PMID 18046974.
  4. ↑ Subissi, A; Evangelista, S; Giachetti, A (1999). "Preclinical Profile of Zofenopril: An Angiotensin Converting Enzyme Inhibitor with Peculiar Cardioprotective Properties". Cardiovascular Drug Reviews. 17 (2): 115. doi:10.1111/j.1527-3466.1999.tb00008.x.
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