ACE inhibitor and thiazide combination

An ACE inhibitor and thiazide combination is a drug combination used to treat hypertension. They are given by oral administration.

Examples

Quinapril/hydrochlorothiazide
Combination of
Quinapril Angiotensin converting enzyme inhibitor
Hydrochlorothiazide Thiazide diuretic
Clinical data
Trade names Accuretic
AHFS/Drugs.com Multum Consumer Information
Pregnancy
category
  • US: D (Evidence of risk)
    ATC code
    Legal status
    Legal status
    Identifiers
    ChemSpider
    KEGG
    Lisinopril/hydrochlorothiazide
    Combination of
    Lisinopril ACE inhibitor
    Hydrochlorothiazide Thiazide diuretic
    Clinical data
    MedlinePlus a601070
    Pregnancy
    category
    • US: D (Evidence of risk)
      Routes of
      administration      		 Oral
      ATC code
      Legal status
      Legal status
      • In general: ℞ (Prescription only)
      Identifiers
      KEGG
        (verify)

      Fosinopril/hydrochlorothiazide

      Fosinopril/hydrochlorothiazide
      Combination of
      Fosinopril Angiotensin converting enzyme inhibitor
      Hydrochlorothiazide Thiazide diuretic
      Clinical data
      Trade names Monopril HCT
      Pregnancy
      category
      • C (1st trimester); D (2nd & 3rd trimesters)
      Routes of
      administration      		 Oral
      ATC code
      Legal status
      Legal status
      • In general: ℞ (Prescription only)

      Fosinopril/hydrochlorothiazide (trade name Monopril HCT) has a boxed warning about its significant risk to cause fetal/neonatal morbidity and mortality when being used during pregnancy (2nd and 3rd trimesters).[4]

      FDA modified its labeling on February, 2009 to include a precaution of drug interaction with gold. "Nitritoid reactions (symptoms include facial flushing, nausea, vomiting and hypotension) have been reported rarely in patients on therapy with injectable gold (sodium aurothiomalate) and concomitant ACE inhibitor therapy including Monopril/Monopril HCT."[5]

      See also

      References

      1. ↑ Accuretic Multum Consumer Information
      2. ↑ "Prinzide Uses, Side Effects & Warnings - Drugs.com". drugs.com.
      3. ↑ "Zestoretic: Uses, Dosage & Side Effects - Drugs.com". drugs.com.
      4. ↑ "fosinopril/hydrochlorothiazide (Rx) - Contraindications & Cautions". Medscape. Retrieved 13 December 2013.
      5. ↑ "Monopril HCT (fosinopril/hydrochlorothiazide) 20/12.5mg and 10/12.5mg Tablets February 2009". FDA.
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