Vitamin D3 24-hydroxylase

Vitamin D3 24-hydroxylase
Identifiers
EC number 1.14.15.16
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Vitamin D3 24-hydroxylase (EC 1.14.15.16, CYP24A1) is an enzyme with systematic name calcitriol,NADPH:oxygen oxidoreductase (24-hydroxylating).[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

(1) calcitriol + NADPH + H+ + O2 calcitetrol + NADP+ + H2O
(2) calcidiol + NADPH + H+ + O2 secalciferol + NADP+ + H2O

Vitamin D3 24-hydroxylase is a heme-thiolate enzyme (P-450).

References

  1. ↑ Masuda S, Strugnell SA, Knutson JC, St-Arnaud R, Jones G (February 2006). "Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2". Biochimica et Biophysica Acta. 1761 (2): 221–34. doi:10.1016/j.bbalip.2006.01.004. PMID 16516540.
  2. ↑ Hamamoto H, Kusudo T, Urushino N, Masuno H, Yamamoto K, Yamada S, Kamakura M, Ohta M, Inouye K, Sakaki T (July 2006). "Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid residues responsible for species-based difference of CYP24A1 between humans and rats". Molecular Pharmacology. 70 (1): 120–8. doi:10.1124/mol.106.023275. PMID 16617161.
  3. ↑ Sakaki T, Kagawa N, Yamamoto K, Inouye K (January 2005). "Metabolism of vitamin D3 by cytochromes P450". Frontiers in Bioscience. 10: 119–34. doi:10.2741/1514. PMID 15574355.
  4. ↑ Prosser DE, Kaufmann M, O'Leary B, Byford V, Jones G (July 2007). "Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone". Proceedings of the National Academy of Sciences of the United States of America. 104 (31): 12673–8. doi:10.1073/pnas.0702093104. PMC 1937525. PMID 17646648.
  5. ↑ Kusudo T, Sakaki T, Abe D, Fujishima T, Kittaka A, Takayama H, Hatakeyama S, Ohta M, Inouye K (September 2004). "Metabolism of A-ring diastereomers of 1alpha,25-dihydroxyvitamin D3 by CYP24A1". Biochemical and Biophysical Research Communications. 321 (4): 774–82. doi:10.1016/j.bbrc.2004.07.040. PMID 15358094.
  6. ↑ Sawada N, Kusudo T, Sakaki T, Hatakeyama S, Hanada M, Abe D, Kamao M, Okano T, Ohta M, Inouye K (April 2004). "Novel metabolism of 1 alpha,25-dihydroxyvitamin D3 with C24-C25 bond cleavage catalyzed by human CYP24A1". Biochemistry. 43 (15): 4530–7. doi:10.1021/bi030207f. PMID 15078099.
  7. ↑ Prosser DE, Jones G (December 2004). "Enzymes involved in the activation and inactivation of vitamin D". Trends in Biochemical Sciences. 29 (12): 664–73. doi:10.1016/j.tibs.2004.10.005. PMID 15544953.
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