Vincenzo Cerundolo

Enzo Cerundolo
FRS FMedSci
Born Vincenzo Cerundolo[1]
Education University of Oxford (MA)
University of Padua (MD, PhD)[2]
Scientific career
Institutions University of Oxford
John Radcliffe Hospital
Website www.rdm.ox.ac.uk/people/vincenzo-cerundolo

Vincenzo Cerundolo FRS FMedSci[3][4] is director of the Medical Research Council (MRC) human immunology unit at the John Radcliffe Hospital and a Professor at the University of Oxford.[5][6] He is also a Fellow of Merton College, Oxford.[7]

Cerundolo is known for his discoveries in processing and presentation of peptides and lipids to T cells.[3] He was first to demonstrate that TAP genes within the major histocompatibility complex (MHC) transport peptides presented by MHC class I molecules and describe a novel clinical syndrome in patients with defective TAP genes.[3] Cerundolo characterised the relationship between the length of peptides and their binding affinity to MHC class I molecules, explaining the homogeneous length of peptides isolated from MHC class I molecules.[3]

He demonstrated that proteasome dependent degradation of antigenic proteins plays a key role not only in controlling presentation of intracellular, but also of extracellular proteins taken up by antigen presenting cells, hence defining the mechanism for the process known as cross-presentation.[3]

He characterised the structural and kinetic mechanisms by which lipids bind to CD1 molecules and are recognized by T cells and demonstrated that harnessing CD1 restricted Natural killer T cell (NKT) cells enhances antigen specific antibody and T cell responses.[3] These seminal findings have opened up novel therapeutic strategies to enhance immune responses against cancer and pathogens.[3]

References

  1. ↑ MRC, Medical Research Council, (19 August 2015). "Professor Vincenzo (Enzo) Cerundolo". mrc.ukri.org.
  2. ↑ Vincenzo Cerundolo's Entry at ORCID
  3. 1 2 3 4 5 6 7 Anon (2018). "Professor Vincenzo Cerundolo FMedSci FRS". London: Royal Society. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --"Archived copy". Archived from the original on 2016-11-11. Retrieved 2016-03-09.
  4. ↑ "Professor Vincenzo Cerundolo - The Academy of Medical Sciences". acmedsci.ac.uk.
  5. ↑ "Vincenzo Cerundolo — Radcliffe Department of Medicine". www.rdm.ox.ac.uk.
  6. ↑ Vincenzo Cerundolo publications from Europe PubMed Central
  7. ↑ "Professor Vincenzo Cerundolo". www.merton.ox.ac.uk.

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