Neil Brockdorff

Neil Brockdorff
FRS FMedSci FRSB
Alma mater University of Glasgow (PhD)[1]
Awards EMBO Member (1999)[2]
Scientific career
Fields Developmental epigenetics
X inactivation[3]
Institutions University of Oxford
Thesis The effect of oestradiol-17β on the ribonucleases and ribonuclease inhibitor of immature rat uterus (1985)
Influences Mary F. Lyon[4][3]
Website www.bioch.ox.ac.uk/research/brockdorff

Neil Brockdorff FRS FMedSci FRSB[5] is a Wellcome Trust Principal Research Fellow and professor in the department of biochemistry at the University of Oxford.[6][7] Brockdorff's research investigates gene and genome regulation in mammalian development.[8] His research investigates the molecular basis of X-inactivation, the process that evolved in mammals to equalise X chromosome gene expression levels in XX females relative to XY males.[8]

X inactivation is an important model for understanding how epigenetic mechanisms, for example modification of DNA and histone proteins around which DNA is packaged, contribute to gene regulation in developmental biology.[8][9] In earlier work Brockdorff demonstrated that an unusual functional RNA molecule, XIST, controls the X inactivation process.[10][11] Building on this finding he has elucidated key steps in XIST gene regulation during early development, and has defined major pathways through which XIST RNA induces chromosome wide gene silencing.[8][4][12][13]

References

  1. ↑ Brockdorff, Neil Alexander Steven (1985). The effect of oestradiol-17β on the ribonucleases and ribonuclease inhibitor of immature rat uterus. jisc.ac.uk (PhD thesis). University of Glasgow. OCLC 301485805. EThOS uk.bl.ethos.379306.
  2. ↑ "Find people in the EMBO Communities". people.embo.org. Retrieved 12 June 2018.
  3. 1 2 Brockdorff, Neil (2017). "Polycomb complexes in X chromosome inactivation". Philosophical Transactions of the Royal Society B. 372 (1733). doi:10.1098/rstb.2017.0021. ISSN 0962-8436. PMC 5627167. PMID 28947664.
  4. 1 2 Heard, Edith; Brockdorff, Neil (2017). "Preface: X-chromosome inactivation and Mary Lyon". Philosophical Transactions of the Royal Society B. 372 (1733). doi:10.1098/rstb.2016.0353. ISSN 0962-8436. PMC 5627156. PMID 28947653.
  5. ↑ "Professor Neil Brockdorff - The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 12 June 2018.
  6. ↑ "Brockdorff Lab". sites.google.com. Retrieved 12 June 2018.
  7. ↑ "Prof Neil Brockdorff Page - Department of Biochemistry, University of Oxford". www.bioch.ox.ac.uk. Retrieved 12 June 2018.
  8. 1 2 3 4 Anon (2018). "Professor Neil Brockdorff FRS". royalsociety.org. London: Royal Society. Archived from the original on 2018-06-06. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  9. ↑ de Napoles, Mariana; Mermoud, Jacqueline E.; Wakao, Rika; Tang, Y.Amy; Endoh, Mitusuhiro; Appanah, Ruth; Nesterova, Tatyana B.; Silva, Jose; Otte, Arie P.; Vidal, Miguel; Koseki, Haruhiko; Brockdorff, Neil (2004). "Polycomb Group Proteins Ring1A/B Link Ubiquitylation of Histone H2A to Heritable Gene Silencing and X Inactivation". Developmental Cell. 7 (5): 663–676. doi:10.1016/j.devcel.2004.10.005. ISSN 1534-5807. PMID 15525528.
  10. ↑ Penny, Graeme D.; Kay, Graham F.; Sheardown, Steven A.; Rastan, Sohaila; Brockdorff, Neil (1996). "Requirement for Xist in X chromosome inactivation". Nature. 379 (6561): 131–137. doi:10.1038/379131a0. ISSN 0028-0836. PMID 8538762.
  11. ↑ Brockdorff, Neil; Ashworth, Alan; Kay, Graham F.; McCabe, Veronica M.; Norris, Dominic P.; Cooper, Penny J.; Swift, Sally; Rastan, Sohaila (1992). "The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus". Cell. 71 (3): 515–526. doi:10.1016/0092-8674(92)90519-I. ISSN 0092-8674. PMID 1423610.
  12. ↑ Neil Brockdorff publications from Europe PubMed Central
  13. ↑ Stock, Julie K.; Giadrossi, Sara; Casanova, Miguel; Brookes, Emily; Vidal, Miguel; Koseki, Haruhiko; Brockdorff, Neil; Fisher, Amanda G.; Pombo, Ana (2007). "Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells". Nature Cell Biology. 9 (12): 1428–1435. doi:10.1038/ncb1663. ISSN 1465-7392. PMID 18037880.

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