Dimitri Kullmann

Dimitri Kullmann
FRS FMedSci MAE
Born Dimitri Michael Kullmann
1958 (age 59–60)
London, England
Alma mater University of Oxford (BM BCh, DPhil)
Awards Baly Medal (2017)[1]
Scientific career
Fields
Institutions
Thesis Central actions of muscle receptors (1984)
Doctoral advisor Julian Jack[3]
Influences Roger Nicoll[1]
Website www.ucl.ac.uk/ion/research/synaptopathies/principal-investigators/dimitri-m-kullmann

Dimitri Michael Kullmann (born 1958, London) FRS FMedSci MAE is a professor of neurology at the UCL Institute of Neurology,[1] University College London (UCL), and leads the synaptopathies initiative funded by the Wellcome Trust.[4] Kullmann is a member of the Queen Square Centre For Neuromuscular Disease[5] and a consultant neurologist at the National Hospital for Neurology and Neurosurgery.[2]

Education

Kullmann studied Medicine (BM BCh, DPhil)[3] at the University of Oxford and St Thomas's Hospital Medical School at the University of London.[1] His postgraduate research was supervised by Julian Jack.[3]

Research and career

Kullmann's research[2][6] investigates how synapses function in health and disease.[7] His laboratory helped to show how neurotransmitters activate different receptor subtypes in and around synapses, and resolved some controversies about the mechanisms of long-term changes in synaptic strength.[7] Genetic and autoimmune disorders of synaptic proteins (‘synaptopathies’) provide insights into the mechanisms of a broad range of neurological diseases including epilepsy and migraine.[7] Together with his colleagues, Kullmann has used these insights to devise gene therapy strategies that could be used to treat intractable epilepsy.[7][2]

The Kullmann lab[2][6] has contributed to the discovery and elucidation of silent synapses,[8] glutamate spillover, tonic inhibition,[9] long-term potentiation in interneurons,[10] neurological channelopathies[11] and Synaptopathies, gene therapy for epilepsy,[12] and mechanisms of neural oscillations.[13] Kullman serves as the editor-in-chief of the scientific journal Brain[14] and on the editorial board of the journal Neuron.[15] Before working at UCL, he did postdoctoral research with Roger Nicoll at the University of California, San Francisco.[1]

Awards and honours

Kullmann was awarded the University Gold Medal in Medicine by the University of London, in 1986.[1] and the Baly Medal by the Royal College of Physicians in 2017.[1] He was elected a Guarantor of Brain in 2000,[16] elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2001,[17] a Corresponding Fellow of the American Neurological Association in 2013[18], a member of the Academia Europaea (MAE) in 2017[19] and a Fellow of the Royal Society (FRS) in 2018.[7]

References

  1. 1 2 3 4 5 6 7 8 "Prof Dimitri Michael Kullmann: Iris View Profile". iris.ucl.ac.uk. University of London. Retrieved 2016-10-02.
  2. 1 2 3 4 5 6 7 8 Dimitri Kullmann publications indexed by Google Scholar Edit this at Wikidata
  3. 1 2 3 Kullman, Dimitri Michael (1984). Central actions of muscle receptors. bodleian.ox.ac.uk (DPhil thesis). University of Oxford. OCLC 59330270. EThOS uk.bl.ethos.353099.
  4. ↑ "Synaptopathies". ucl.ac.uk. 2014-07-17. Retrieved 2016-10-02.
  5. ↑ "CNMD". ucl.ac.uk. Retrieved 2016-11-02.
  6. 1 2 Dimitri Kullmann publications from Europe PubMed Central
  7. 1 2 3 4 5 Anon (2018). "Professor Dimitri Kullmann FMedSci FRS". royalsociety.org. London: Royal Society. Archived from the original on 2018-05-24. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  8. ↑ Kullmann, Dimitri M. (1994). "Amplitude fluctuations of". Neuron. 12 (5): 1111–1120. doi:10.1016/0896-6273(94)90318-2. PMID 7910467.
  9. ↑ Semyanov, Alexey; Walker, Matthew C.; Kullmann, Dimitri M.; Silver, R.Angus (2004). "Tonically active GABAA receptors: modulating gain and maintaining the tone". Trends in Neurosciences. 27 (5): 262–269. doi:10.1016/j.tins.2004.03.005. ISSN 0166-2236. PMID 15111008.
  10. ↑ Lamsa, Karri P.; Heeroma, Joost H.; Somogyi, Peter; Rusakov, Dmitri A.; Kullmann, Dimitri M. (2007). "Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit". Science. 315 (5816): 1262–1266. doi:10.1126/science.1137450. ISSN 1095-9203. PMC 3369266. PMID 17332410.
  11. ↑ Kullmann, Dimitri M. (2010). "Neurological channelopathies". Annual Review of Neuroscience. 33: 151–172. doi:10.1146/annurev-neuro-060909-153122. ISSN 1545-4126. PMID 20331364.
  12. ↑ Wykes, Robert C.; Heeroma, Joost H.; Mantoan, Laura; Zheng, Kaiyu; MacDonald, Douglas C.; Deisseroth, Karl; Hashemi, Kevan S.; Walker, Matthew C.; Schorge, Stephanie (2012). "Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy". Science Translational Medicine. 4 (161): 161ra152. doi:10.1126/scitranslmed.3004190. ISSN 1946-6242. PMC 3605784. PMID 23147003.
  13. ↑ Akam, Thomas; Oren, Iris; Mantoan, Laura; Ferenczi, Emily; Kullmann, Dimitri M. (2012). "Oscillatory dynamics in the hippocampus support dentate gyrus–CA3 coupling". Nature Neuroscience. 15 (5): 763–768. doi:10.1038/nn.3081. ISSN 1546-1726. PMC 3378654. PMID 22466505.
  14. ↑ "Editorial board | Brain". Brain.oxfordjournals.org. 2016-09-26. Retrieved 2016-10-02.
  15. ↑ "Editorial Board: Neuron". www.cell.com.
  16. ↑ "Guarantors of Brain". Guarantors of Brain. Retrieved 2016-08-11.
  17. ↑ "Professor Dimitri Kullmann FMedSci". acmedsci.ac.uk. Retrieved 2016-10-02.
  18. ↑ "American Neurological Association (ANA)". Myana.org. Retrieved 2016-11-01.
  19. ↑ Hoffmann, Ilire Hasani, Robert. "Academy of Europe: Kullmann Dimitri". www.ae-info.org.

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