Very-long-chain 3-oxoacyl-CoA reductase

Very-long-chain 3-oxoacyl-CoA reductase
Identifiers
EC number 1.1.1.330
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330, very-long-chain 3-ketoacyl-CoA reductase, very-long-chain beta-ketoacyl-CoA reductase, KCR (gene), IFA38 (gene)) is an enzyme with systematic name (3R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ a very-long-chain 3-oxoacyl-CoA + NADPH + H+

This microsomal complex extendins palmitoyl-CoA and stearoyl-CoA (and their modified forms) to very-long-chain acyl CoAs.

References

  1. ↑ Beaudoin, F.; Gable, K.; Sayanova, O.; Dunn, T.; Napier, J.A. (2002). "A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal β-keto-reductase". J. Biol. Chem. 277 (13): 11481–11488. doi:10.1074/jbc.M111441200. PMID 11792704.
  2. ↑ Han, G.; Gable, K.; Kohlwein, S.D.; Beaudoin, F.; Napier, J.A.; Dunn, T.M. (2002). "The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase". J. Biol. Chem. 277 (38): 35440–35449. doi:10.1074/jbc.M205620200. PMID 12087109.
  3. ↑ Beaudoin, F.; Wu, X.; Li, F.; Haslam, R.P.; Markham, J.E.; Zheng, H.; Napier, J.A.; Kunst, L. (2009). "Functional characterization of the Arabidopsis β-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase". Plant Physiol. 150 (3): 1174–1191. doi:10.1104/pp.109.137497. PMC 2705042. PMID 19439572.
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