Hydroxysteroid dehydrogenase

Steroid numbering.

Hydroxysteroid dehydrogenases (HSDs) are a group of alcohol oxidoreductases that catalyze the dehydrogenation of hydroxysteroids. These enzymes also catalyze the reverse reaction, acting as ketosteroid reductases (KSRs).

There are four types, classified by the number of the position acted upon:

Carbon17β-Hydroxysteroid17-Ketosteroid
3β-HSDPregnenoloneProgesterone
3β-HSD17α-Hydroxypregnenolone17α-Hydroxyprogesterone
3β-HSDDehydroepiandrosteroneAndrostenedione
3β-HSDAndrostenediolTestosterone
11β-HSDCortisolCortisone
17β-HSDAndrostenedioneTestosterone
17β-HSDAndrostanedioneDihydrotestosterone
17β-HSDEstroneEstradiol
20β-HSDProgesterone20α-Dihydroprogesterone

See also

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.