UDP-glucuronic acid dehydrogenase

UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)
Identifiers
EC number 1.1.1.305
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating) (EC 1.1.1.305, UDP-GlcUA decarboxylase, ArnADH) is an enzyme with systematic name UDP-glucuronate:NAD+ oxidoreductase (decarboxylating).[1][2][3][4][5] This enzyme catalyses the following chemical reaction

UDP-glucuronate + NAD+ UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+

The activity is part of a bifunctional enzyme also performing the reaction of EC 2.1.2.13 (UDP-4-amino-4-deoxy-L-arabinose formyltransferase).

References

  1. ↑ Breazeale, S.D.; Ribeiro, A.A.; McClerren, A.L.; Raetz, C.R.H. (2005). "A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-amino-4-deoxy-L-arabinose. Identification and function of UDP-4-deoxy-4-formamido-L-arabinose". J. Biol. Chem. 280 (14): 14154–14167. doi:10.1074/jbc.M414265200. PMID 15695810.
  2. ↑ Gatzeva-Topalova, P.Z.; May, A.P.; Sousa, M.C. (2004). "Crystal structure of Escherichia coli ArnA (PmrI) decarboxylase domain. A key enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance". Biochemistry. 43 (42): 13370–13379. doi:10.1021/bi048551f. PMC 2680612. PMID 15491143.
  3. ↑ Williams, G.J.; Breazeale, S.D.; Raetz, C.R.H.; Naismith, J.H. (2005). "Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis". J. Biol. Chem. 280 (24): 23000–23008. doi:10.1074/jbc.M501534200. PMC 3326539. PMID 15809294.
  4. ↑ Gatzeva-Topalova, P.Z.; May, A.P.; Sousa, M.C. (2005). "Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance". Structure. 13 (6): 929–942. doi:10.1016/j.str.2005.03.018. PMC 2997725. PMID 15939024.
  5. ↑ Yan, A.; Guan, Z.; Raetz, C.R.H. (2007). "An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli". J. Biol. Chem. 282 (49): 36077–36089. doi:10.1074/jbc.M706172200. PMC 2613183. PMID 17928292.
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