Tricetin 3',4',5'-O-trimethyltransferase

Tricetin 3',4',5'-O-trimethyltransferase
Identifiers
EC number 2.1.1.169
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Tricetin 3',4',5'-O-trimethyltransferase (EC 2.1.1.169, FOMT, TaOMT1, TaCOMT1, TaOMT2) is an enzyme with systematic name S-adenosyl-L-methionine:tricetin 3',4',5'-O-trimethyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

3 S-adenosyl-L-methionine + tricetin 3 S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin (overall reaction)
(1a) S-adenosyl-L-methionine + tricetin S-adenosyl-L-homocysteine + 3'-O-methyltricetin
(1b) S-adenosyl-L-methionine + 3'-O-methyltricetin S-adenosyl-L-homocysteine + 3',5'-O-dimethyltricetin
(1c) S-adenosyl-L-methionine + 3',5'-O-dimethyltricetin S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin

The enzyme from Triticum aestivum catalyses the sequential O-methylation of tricetin via 3'-O-methyltricetin, 3',5'-O-methyltricetin to 3',4',5'-O-trimethyltricetin.

References

  1. ↑ Kornblatt JA, Zhou JM, Ibrahim RK (May 2008). "Structure-activity relationships of wheat flavone O-methyltransferase: a homodimer of convenience". The FEBS Journal. 275 (9): 2255–66. doi:10.1111/j.1742-4658.2008.06377.x. PMID 18397325.
  2. ↑ Zhou JM, Gold ND, Martin VJ, Wollenweber E, Ibrahim RK (July 2006). "Sequential O-methylation of tricetin by a single gene product in wheat". Biochimica et Biophysica Acta. 1760 (7): 1115–24. doi:10.1016/j.bbagen.2006.02.008. PMID 16730127.
  3. ↑ Zhou JM, Seo YW, Ibrahim RK (April 2009). "Biochemical characterization of a putative wheat caffeic acid O-methyltransferase". Plant Physiology and Biochemistry. 47 (4): 322–6. doi:10.1016/j.plaphy.2008.11.011. PMID 19211254.
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