TRNA (cytidine56-2'-O)-methyltransferase

tRNA (cytidine56-2'-O)-methyltransferase
Identifiers
EC number 2.1.1.206
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

tRNA (cytidine56-2'-O)-methyltransferase (EC 2.1.1.206, aTrm56, tRNA ribose 2'-O-methyltransferase aTrm56, PAB1040 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine56-2'-O)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytidine56 in tRNA S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA

The archaeal enzyme specifically catalyses the S-adenosyl-L-methionine dependent 2'-O-ribose methylation of cytidine at position 56 in tRNA transcripts.

References

  1. ↑ Renalier MH, Joseph N, Gaspin C, Thebault P, Mougin A (July 2005). "The Cm56 tRNA modification in archaea is catalyzed either by a specific 2'-O-methylase, or a C/D sRNP". Rna. 11 (7): 1051–63. doi:10.1261/rna.2110805. PMC 1370790. PMID 15987815.
  2. ↑ Kuratani M, Bessho Y, Nishimoto M, Grosjean H, Yokoyama S (January 2008). "Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA". Journal of Molecular Biology. 375 (4): 1064–75. doi:10.1016/j.jmb.2007.11.023. PMID 18068186.
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