Pentalenene oxygenase

Pentalenene oxygenase
Identifiers
EC number 1.14.13.133
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Pentalenene oxygenase (EC 1.14.13.133, PtlI) is an enzyme with systematic name pentalenene,NADPH:oxygen 13-oxidoreductase.[1] This enzyme catalyses the following chemical reaction

pentalenene + 2 NADPH + 2 H+ + 2 O2 pentalen-13-al + 2 NADP+ + 3 H2O (overall reaction)
(1a) pentalenene + NADPH + H+ + O2 pentalen-13-ol + NADP+ + H2O
(1b) pentalen-13-ol + NADPH + H+ + O2 pentalen-13-al + NADP+ + 2 H2O

Pentalenene oxygenase is a heme-thiolate protein (P-450).

References

  1. Quaderer, R.; Omura, S.; Ikeda, H.; Cane, D.E. (2006). "Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlI, a cytochrome P450 of Streptomyces avermitilis". J. Am. Chem. Soc. 128 (40): 13036–13037. doi:10.1021/ja0639214. PMC 2533730. PMID 17017767.
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