POLE4

POLE4
Identifiers
AliasesPOLE4, YHHQ1, p12, polymerase (DNA) epsilon 4, accessory subunit, DNA polymerase epsilon 4, accessory subunit
External IDsMGI: 1914229 HomoloGene: 41339 GeneCards: POLE4
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p12Start74,958,492 bp[1]
End74,970,128 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

56655

66979

Ensembl

ENSG00000115350

ENSMUSG00000030042

UniProt

Q9NR33

Q9CQ36

RefSeq (mRNA)

NM_019896

NM_025882

RefSeq (protein)

NP_063949

NP_080158

Location (UCSC)Chr 2: 74.96 – 74.97 MbChr 6: 82.62 – 82.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene.[5]

Function

POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000115350 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030042 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: Polymerase (DNA-directed), epsilon 4, accessory subunit".

Further reading

  • Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon". Nucleic Acids Res. 31 (19): 5568–75. doi:10.1093/nar/gkg765. PMC 206465. PMID 14500819.
  • Li Y, Pursell ZF, Linn S (2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J. Biol. Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.
  • Wang YL, Faiola F, Xu M, Pan S, Martinez E (2008). "Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein". J. Biol. Chem. 283 (49): 33808–15. doi:10.1074/jbc.M806936200. PMC 2590711. PMID 18838386.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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