HFM1

HFM1
Identifiers
Aliases	HFM1, MER3, POF9, SEC63D1, Si-11, Si-11-6, helicase, ATP-dependent DNA helicase homolog, ATP dependent DNA helicase homolog
External IDs	MGI: 3036246 HomoloGene: 87103 GeneCards: HFM1
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	91,404,869 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	106,926,321 bp[2]
Gene ontology
Molecular function	• ATP binding; • hydrolase activity; • nucleotide binding; • nucleic acid binding; • helicase activity; • ATP-dependent RNA helicase activity;
Cellular component	• nucleolus; • cytoplasm;
Biological process	• resolution of meiotic recombination intermediates; • meiotic cell cycle; • RNA secondary structure unwinding;
	Sources:Amigo / QuickGO
Orthologs
	164045
	330149
	ENSG00000162669
	ENSMUSG00000043410
	A2PYH4; C9JQ07
	D3Z4R1
	NM_001017975
	NM_001252516; NM_177873
	NP_001017975
	NP_001239445; NP_808541
	Wikidata
View/Edit Human	View/Edit Mouse

HFM1 is a gene that in humans encodes a protein necessary for homologous recombination of chromosomes.^[5] Biallelic mutations in HFM1 cause recessive primary ovarian insufficiency.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000162669 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043410 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 Wang J, Zhang W, Jiang H, Wu BL (March 2014). "Mutations in HFM1 in recessive primary ovarian insufficiency". The New England Journal of Medicine. 370 (10): 972–4. doi:10.1056/NEJMc1310150. PMID 24597873.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000162669 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043410 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[WangZhang2014-5] 1 2 Wang J, Zhang W, Jiang H, Wu BL (March 2014). "Mutations in HFM1 in recessive primary ovarian insufficiency". The New England Journal of Medicine. 370 (10): 972–4. doi:10.1056/NEJMc1310150. PMID 24597873.