Naftifine

Naftifine
Clinical data
Trade names	Exoderil
AHFS/Drugs.com	Monograph
MedlinePlus	a688020
ATC code	D01AE22 (WHO) ;
Identifiers
	IUPAC name (2E)-N-methyl-N-(1-naphthylmethyl)-3-phenylprop-2-en-1-amine;
CAS Number	65472-88-0 ;
PubChem CID	47641;
DrugBank	DB00735 ;
ChemSpider	66071 ;
UNII	4FB1TON47A;
ChEBI	CHEBI:7451 ;
ChEMBL	CHEMBL626 ;
Chemical and physical data
Formula	C21H21N
Molar mass	287.398 g/mol
(what is this?) (verify)

Naftifine (brand name Exoderil) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections).

Naftifine has triple action: antifungal, antibacterial and anti-inflammatory. Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme.^[1]^[2] The half-life is approximately 2–3 days.^[2] The metabolites are excreted in the urine and feces.^[3]

References

↑ Robertson Dirk B, Maibach Howard I, "Chapter 61. Dermatologic Pharmacology" (Chapter). Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor: Basic & Clinical Pharmacology, 11e: http://www.accesspharmacy.com/content.aspx?aID=4517257.
1 2 Micromedex DRUGDEX Drug Point: Naftifine Hydrochloride. Accessed at www.thomsonhc.com/../BeginWith#secN10184, February 18, 2010.
↑ AccessPharmacy: Drug Monographs: Naftifine. Accessed at http://www.accesspharmacy.com/drugContentPopup.aspx?mid=6620&section=10, February 18, 2010.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[Robertson-1] Robertson Dirk B, Maibach Howard I, "Chapter 61. Dermatologic Pharmacology" (Chapter). Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor: Basic & Clinical Pharmacology, 11e: http://www.accesspharmacy.com/content.aspx?aID=4517257.

[Micromedex-2] 1 2 Micromedex DRUGDEX Drug Point: Naftifine Hydrochloride. Accessed at www.thomsonhc.com/../BeginWith#secN10184, February 18, 2010.

[3] AccessPharmacy: Drug Monographs: Naftifine. Accessed at http://www.accesspharmacy.com/drugContentPopup.aspx?mid=6620&section=10, February 18, 2010.