NADP-retinol dehydrogenase

NADP-retinol dehydrogenase
Identifiers
EC number 1.1.1.300
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

NADP-retinol dehydrogenase (EC 1.1.1.300, all-trans retinal reductase, all-trans-retinol dehydrogenase, NADP(H)-dependent retinol dehydrogenase/reductase, RDH11, RDH12, RDH13, RDH14, retinol dehydrogenase 12, retinol dehydrogenase 14, retinol dehydrogenase (NADP+), RalR1, PSDR1) is an enzyme with systematic name retinol:NADP+ oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

retinol + NADP+ retinal + NADPH + H+

This enzyme has greater catalytic efficiency in the reductive direction.

References

  1. ↑ Belyaeva, O.V.; Korkina, O.V.; Stetsenko, A.V.; Kim, T.; Nelson, P.S.; Kedishvili, N.Y. (2005). "Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids". Biochemistry. 44 (18): 7035–7047. doi:10.1021/bi050226k. PMC 2679700. PMID 15865448.
  2. ↑ Belyaeva, O.V.; Korkina, O.V.; Stetsenko, A.V.; Kedishvili, N.Y. (2008). "Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity". FEBS J. 275 (1): 138–147. doi:10.1111/j.1742-4658.2007.06184.x. PMC 2573044. PMID 18039331.
  3. ↑ Haeseleer, F.; Huang, J.; Lebioda, L.; Saari, J.C.; Palczewski, K. (1998). "Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal". J. Biol. Chem. 273 (34): 21790–21799. doi:10.1074/jbc.273.34.21790. PMID 9705317.
  4. ↑ Kedishvili, N.Y.; Chumakova, O.V.; Chetyrkin, S.V.; Belyaeva, O.V.; Lapshina, E.A.; Lin, D.W.; Matsumura, M.; Nelson, P.S. (2002). "Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1)". J. Biol. Chem. 277: 28909–28915. doi:10.1074/jbc.M202588200. PMID 12036956.
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